Cargando…

Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding

BACKGROUND: Rebleeding is associated with poor outcomes in upper gastrointestinal bleeding (UGIB). Identifying predictors of rebleeding can assist in risk assessment. The aim of the study is to investigate the factors affecting rebleeding in patients with UGIB admitted to the emergency department. M...

Descripción completa

Detalles Bibliográficos
Autores principales: Tatlıparmak, Ali Cankut, Dikme, Özlem, Dikme, Özgür, Topaçoğlu, Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482764/
https://www.ncbi.nlm.nih.gov/pubmed/36128193
http://dx.doi.org/10.7717/peerj.14061
_version_ 1784791526121930752
author Tatlıparmak, Ali Cankut
Dikme, Özlem
Dikme, Özgür
Topaçoğlu, Hakan
author_facet Tatlıparmak, Ali Cankut
Dikme, Özlem
Dikme, Özgür
Topaçoğlu, Hakan
author_sort Tatlıparmak, Ali Cankut
collection PubMed
description BACKGROUND: Rebleeding is associated with poor outcomes in upper gastrointestinal bleeding (UGIB). Identifying predictors of rebleeding can assist in risk assessment. The aim of the study is to investigate the factors affecting rebleeding in patients with UGIB admitted to the emergency department. METHODS: This retrospective, observational, cross-sectional study was conducted on patients with UGIB presented to the emergency department. Patients who did not arrest in the first 24 h, who were not diagnosed with GI malignancy, and who were clinically diagnosed with UGIB were included in the study. Patient demographic characteristics, hemodynamic parameters, patient parameters, and bleeding that may affect rebleeding were evaluated. The primary endpoint was rebleeding within 7 days. RESULTS: The study included 371 patients. A total of 55 patients (14.8%) had rebleeding within 7 days, and 62 patients (16.7%) presented without bleeding manifestations. Rebleeding rates were higher in those who presented with bloody or coffee-ground vomitus, had a diagnosis of cancer, had blood in their nasogastric tube, and had peptic ulcers due to endoscopy. Mean cell hemoglobin concentration, lymphocyte, albumin, and total protein values of patients with rebleeding were low; red blood cell distribution width, neutrophil count, platelet distribution width (PDW), and neutrophil lymphocyte ratio were high. In-hospital mortality and 30-day mortality values of patients with rebleeding were significantly increased. In the multivariate analysis, cancer, PDW, and total protein levels were statistically significant. CONCLUSION: The presence of cancer, low total protein level, and high PDW are effective parameters in predicting 7-day rebleeding in patients with UGIB admitted to the emergency department.
format Online
Article
Text
id pubmed-9482764
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher PeerJ Inc.
record_format MEDLINE/PubMed
spelling pubmed-94827642022-09-19 Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding Tatlıparmak, Ali Cankut Dikme, Özlem Dikme, Özgür Topaçoğlu, Hakan PeerJ Emergency and Critical Care BACKGROUND: Rebleeding is associated with poor outcomes in upper gastrointestinal bleeding (UGIB). Identifying predictors of rebleeding can assist in risk assessment. The aim of the study is to investigate the factors affecting rebleeding in patients with UGIB admitted to the emergency department. METHODS: This retrospective, observational, cross-sectional study was conducted on patients with UGIB presented to the emergency department. Patients who did not arrest in the first 24 h, who were not diagnosed with GI malignancy, and who were clinically diagnosed with UGIB were included in the study. Patient demographic characteristics, hemodynamic parameters, patient parameters, and bleeding that may affect rebleeding were evaluated. The primary endpoint was rebleeding within 7 days. RESULTS: The study included 371 patients. A total of 55 patients (14.8%) had rebleeding within 7 days, and 62 patients (16.7%) presented without bleeding manifestations. Rebleeding rates were higher in those who presented with bloody or coffee-ground vomitus, had a diagnosis of cancer, had blood in their nasogastric tube, and had peptic ulcers due to endoscopy. Mean cell hemoglobin concentration, lymphocyte, albumin, and total protein values of patients with rebleeding were low; red blood cell distribution width, neutrophil count, platelet distribution width (PDW), and neutrophil lymphocyte ratio were high. In-hospital mortality and 30-day mortality values of patients with rebleeding were significantly increased. In the multivariate analysis, cancer, PDW, and total protein levels were statistically significant. CONCLUSION: The presence of cancer, low total protein level, and high PDW are effective parameters in predicting 7-day rebleeding in patients with UGIB admitted to the emergency department. PeerJ Inc. 2022-09-15 /pmc/articles/PMC9482764/ /pubmed/36128193 http://dx.doi.org/10.7717/peerj.14061 Text en © 2022 Tatlıparmak et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, reproduction and adaptation in any medium and for any purpose provided that it is properly attributed. For attribution, the original author(s), title, publication source (PeerJ) and either DOI or URL of the article must be cited.
spellingShingle Emergency and Critical Care
Tatlıparmak, Ali Cankut
Dikme, Özlem
Dikme, Özgür
Topaçoğlu, Hakan
Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
title Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
title_full Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
title_fullStr Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
title_full_unstemmed Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
title_short Cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
title_sort cancer, platelet distribution width, and total protein levels as predictors of rebleeding in upper gastrointestinal bleeding
topic Emergency and Critical Care
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482764/
https://www.ncbi.nlm.nih.gov/pubmed/36128193
http://dx.doi.org/10.7717/peerj.14061
work_keys_str_mv AT tatlıparmakalicankut cancerplateletdistributionwidthandtotalproteinlevelsaspredictorsofrebleedinginuppergastrointestinalbleeding
AT dikmeozlem cancerplateletdistributionwidthandtotalproteinlevelsaspredictorsofrebleedinginuppergastrointestinalbleeding
AT dikmeozgur cancerplateletdistributionwidthandtotalproteinlevelsaspredictorsofrebleedinginuppergastrointestinalbleeding
AT topacogluhakan cancerplateletdistributionwidthandtotalproteinlevelsaspredictorsofrebleedinginuppergastrointestinalbleeding