Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest

Capecitabine is a prodrug of fluorouracil that specifically targets cancer cells, commonly used as monotherapy for metastatic breast and colorectal cancer. Its side effects include nausea, diarrhea, vomiting, abdominal pain, anorexia, palmar-plantar erythrodysesthesia, anemia, and hyperbilirubinemia...

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Detalles Bibliográficos
Autores principales: Muco, Erind, Patail, Haris, Shaik, Ayesha, McMahon, Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Cardiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482813/
https://www.ncbi.nlm.nih.gov/pubmed/36158449
http://dx.doi.org/10.7759/cureus.28184
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author Muco, Erind
Patail, Haris
Shaik, Ayesha
McMahon, Sean
author_facet Muco, Erind
Patail, Haris
Shaik, Ayesha
McMahon, Sean
author_sort Muco, Erind
collection PubMed
description Capecitabine is a prodrug of fluorouracil that specifically targets cancer cells, commonly used as monotherapy for metastatic breast and colorectal cancer. Its side effects include nausea, diarrhea, vomiting, abdominal pain, anorexia, palmar-plantar erythrodysesthesia, anemia, and hyperbilirubinemia. Rarely, this chemotherapy agent has been associated with cardiotoxicity, including cardiac arrest, likely secondary to coronary vasospasm. This case report serves to highlight the unfortunate case of a 32-year-old female who suffered a ventricular fibrillation cardiac arrest three days after initiating capecitabine therapy.
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spelling pubmed-94828132022-09-22 Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest Muco, Erind Patail, Haris Shaik, Ayesha McMahon, Sean Cureus Cardiology Capecitabine is a prodrug of fluorouracil that specifically targets cancer cells, commonly used as monotherapy for metastatic breast and colorectal cancer. Its side effects include nausea, diarrhea, vomiting, abdominal pain, anorexia, palmar-plantar erythrodysesthesia, anemia, and hyperbilirubinemia. Rarely, this chemotherapy agent has been associated with cardiotoxicity, including cardiac arrest, likely secondary to coronary vasospasm. This case report serves to highlight the unfortunate case of a 32-year-old female who suffered a ventricular fibrillation cardiac arrest three days after initiating capecitabine therapy. Cureus 2022-08-19 /pmc/articles/PMC9482813/ /pubmed/36158449 http://dx.doi.org/10.7759/cureus.28184 Text en Copyright © 2022, Muco et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Muco, Erind
Patail, Haris
Shaik, Ayesha
McMahon, Sean
Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest
title Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest
title_full Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest
title_fullStr Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest
title_full_unstemmed Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest
title_short Capecitabine-Associated Coronary Vasospasm and Cardiac Arrest
title_sort capecitabine-associated coronary vasospasm and cardiac arrest
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482813/
https://www.ncbi.nlm.nih.gov/pubmed/36158449
http://dx.doi.org/10.7759/cureus.28184
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