Targeting phosphoglycerate kinase 1 with terazosin improves motor neuron phenotypes in multiple models of amyotrophic lateral sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with heterogeneous aetiology and a complex genetic background. Effective therapies are therefore likely to act on convergent pathways such as dysregulated energy metabolism, linked to multiple neurodegenerative dis...

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Detalles Bibliográficos
Autores principales: Chaytow, Helena, Carroll, Emily, Gordon, David, Huang, Yu-Ting, van der Hoorn, Dinja, Smith, Hannah Louise, Becker, Thomas, Becker, Catherina Gwynne, Faller, Kiterie Maud Edwige, Talbot, Kevin, Gillingwater, Thomas Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482929/
https://www.ncbi.nlm.nih.gov/pubmed/35963713
http://dx.doi.org/10.1016/j.ebiom.2022.104202

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