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Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings
INTRODUCTION AND IMPORTANCE: Follicular cholecystitis (FC) is a rare entity found, it is found in 0.1–1 % of patients with chronic cholecystitis. 1,2 This pathologic finding has been associated with extrahepatic biliary obstruction distal to the gallbladder, such as primary sclerosing cholangitis, c...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482969/ https://www.ncbi.nlm.nih.gov/pubmed/36058158 http://dx.doi.org/10.1016/j.ijscr.2022.107571 |
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author | Piening, Nicholas Zussman, Rachel Markewycz, Hanna Piening, Cole Rossi, Thomas |
author_facet | Piening, Nicholas Zussman, Rachel Markewycz, Hanna Piening, Cole Rossi, Thomas |
author_sort | Piening, Nicholas |
collection | PubMed |
description | INTRODUCTION AND IMPORTANCE: Follicular cholecystitis (FC) is a rare entity found, it is found in 0.1–1 % of patients with chronic cholecystitis. 1,2 This pathologic finding has been associated with extrahepatic biliary obstruction distal to the gallbladder, such as primary sclerosing cholangitis, choledocholithiasis, and distal biliary strictures. CASE PRESENTATION: Our patient is a 32-year-old female with a past medical history significant for obesity presented with symptoms of postprandial nausea and spasmodic abdominal pain. An abdominal ultrasound was performed with findings adenomyosis and possible gallbladder polyps or adherent stones. The patient was referred to surgery and a routine laparoscopic cholecystectomy with liver biopsy was performed. On pathology, the gallbladder was found to have chronic, active follicular cholecystitis with cholelithiasis. Percutaneous needle liver biopsy revealed the following: focal, mild periductal fibrosis, mild portal fibrosis with minimal mixed micro- and macrovesicular steatosis, and no significant steatohepatitis. CLINICAL DISCUSSION: To the best of our knowledge, this is the first documented case of follicular cholecystitis with associated hepatic findings on pathology. Follicular cholecystitis is strongly associated with extrahepatic biliary obstruction distal to the gallbladder, but it has not been previously associated with liver fibrosis. We hope to bring awareness to this rare but significant pathology. CONCLUSION: Our case is unusual due to the findings of hepatic periductal fibrosis with follicular cholecystitis. Follicular cholecystitis is strongly associated with extrahepatic biliary obstruction distal to the gallbladder but it has not been documented it to be associated with any hepatic findings or pathology. |
format | Online Article Text |
id | pubmed-9482969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94829692022-09-20 Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings Piening, Nicholas Zussman, Rachel Markewycz, Hanna Piening, Cole Rossi, Thomas Int J Surg Case Rep Case Report INTRODUCTION AND IMPORTANCE: Follicular cholecystitis (FC) is a rare entity found, it is found in 0.1–1 % of patients with chronic cholecystitis. 1,2 This pathologic finding has been associated with extrahepatic biliary obstruction distal to the gallbladder, such as primary sclerosing cholangitis, choledocholithiasis, and distal biliary strictures. CASE PRESENTATION: Our patient is a 32-year-old female with a past medical history significant for obesity presented with symptoms of postprandial nausea and spasmodic abdominal pain. An abdominal ultrasound was performed with findings adenomyosis and possible gallbladder polyps or adherent stones. The patient was referred to surgery and a routine laparoscopic cholecystectomy with liver biopsy was performed. On pathology, the gallbladder was found to have chronic, active follicular cholecystitis with cholelithiasis. Percutaneous needle liver biopsy revealed the following: focal, mild periductal fibrosis, mild portal fibrosis with minimal mixed micro- and macrovesicular steatosis, and no significant steatohepatitis. CLINICAL DISCUSSION: To the best of our knowledge, this is the first documented case of follicular cholecystitis with associated hepatic findings on pathology. Follicular cholecystitis is strongly associated with extrahepatic biliary obstruction distal to the gallbladder, but it has not been previously associated with liver fibrosis. We hope to bring awareness to this rare but significant pathology. CONCLUSION: Our case is unusual due to the findings of hepatic periductal fibrosis with follicular cholecystitis. Follicular cholecystitis is strongly associated with extrahepatic biliary obstruction distal to the gallbladder but it has not been documented it to be associated with any hepatic findings or pathology. Elsevier 2022-09-01 /pmc/articles/PMC9482969/ /pubmed/36058158 http://dx.doi.org/10.1016/j.ijscr.2022.107571 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Piening, Nicholas Zussman, Rachel Markewycz, Hanna Piening, Cole Rossi, Thomas Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings |
title | Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings |
title_full | Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings |
title_fullStr | Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings |
title_full_unstemmed | Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings |
title_short | Incidental follicular cholecystitis with periductal fibrosis on liver biopsy: Rare findings |
title_sort | incidental follicular cholecystitis with periductal fibrosis on liver biopsy: rare findings |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482969/ https://www.ncbi.nlm.nih.gov/pubmed/36058158 http://dx.doi.org/10.1016/j.ijscr.2022.107571 |
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