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Pituicytoma: A rare case report of sellar and suprasellar tumor

INTRODUCTION: Pituicytomas are low-grade glial tumors in the sellar and suprasellar region. They may be easily confused with pituitary lesions. We review the literature in order to better understand and categorize the natural history, clinical presentations, and treatments. PRESENTATION OF CASE: A 4...

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Autores principales: Shen, Chia-Fang, Liu, Szu-Yuan, Lee, Chung-Hsin, Pan, Szu-Yen, Shen, Chiung-Chyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482998/
https://www.ncbi.nlm.nih.gov/pubmed/36057248
http://dx.doi.org/10.1016/j.ijscr.2022.107553
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author Shen, Chia-Fang
Liu, Szu-Yuan
Lee, Chung-Hsin
Pan, Szu-Yen
Shen, Chiung-Chyi
author_facet Shen, Chia-Fang
Liu, Szu-Yuan
Lee, Chung-Hsin
Pan, Szu-Yen
Shen, Chiung-Chyi
author_sort Shen, Chia-Fang
collection PubMed
description INTRODUCTION: Pituicytomas are low-grade glial tumors in the sellar and suprasellar region. They may be easily confused with pituitary lesions. We review the literature in order to better understand and categorize the natural history, clinical presentations, and treatments. PRESENTATION OF CASE: A 45-year-old female patient who complained of left eye blurred vision for 2 months. The imaging study revealed a solid sellar tumor with marked homogeneous enhancement following intravenous administration of gadolinium, and compression of the optic chiasm. Thus, under the preoperative diagnosis of pituitary macroadenoma, the patient underwent endoscope-assisted surgery via the transsphenoidal approach. The patient recovered well after surgery. The histopathological diagnosis was pituicytoma, WHO grade I. CLINICAL DISCUSSION: Pituicytomas are defined as a circumscribed low-grade glial tumor arising from the neurohypophysis or infundibulum with bipolar spindle cells arranged in a fascicular or storiform pattern (a cartwheel). The clinical symptoms are variable depending on the tumor size and location. They usually present due to mass effect. The radiographic characteristics are not nonspecific. The diagnosis of pituicytoma is based on histopathological evidence. Pituicytomas consist of a solid proliferation of elongated spindle cells arranged in interlacing fascicles and/or in a “storiform” pattern. In immunohistochemical studies, pituicytomas was strongly expressed in TTF-1. CONCLUSION: Pituicytomas are benign, slow-growing glial tumors. It is difficult to diagnosed before operation as its clinical presentations and imaging studies resemble those of non-functional pituitary adenomas. The best chance of successful treatment is gross total resection by the endoscopic approach or transcranial approach.
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spelling pubmed-94829982022-09-20 Pituicytoma: A rare case report of sellar and suprasellar tumor Shen, Chia-Fang Liu, Szu-Yuan Lee, Chung-Hsin Pan, Szu-Yen Shen, Chiung-Chyi Int J Surg Case Rep Case Report INTRODUCTION: Pituicytomas are low-grade glial tumors in the sellar and suprasellar region. They may be easily confused with pituitary lesions. We review the literature in order to better understand and categorize the natural history, clinical presentations, and treatments. PRESENTATION OF CASE: A 45-year-old female patient who complained of left eye blurred vision for 2 months. The imaging study revealed a solid sellar tumor with marked homogeneous enhancement following intravenous administration of gadolinium, and compression of the optic chiasm. Thus, under the preoperative diagnosis of pituitary macroadenoma, the patient underwent endoscope-assisted surgery via the transsphenoidal approach. The patient recovered well after surgery. The histopathological diagnosis was pituicytoma, WHO grade I. CLINICAL DISCUSSION: Pituicytomas are defined as a circumscribed low-grade glial tumor arising from the neurohypophysis or infundibulum with bipolar spindle cells arranged in a fascicular or storiform pattern (a cartwheel). The clinical symptoms are variable depending on the tumor size and location. They usually present due to mass effect. The radiographic characteristics are not nonspecific. The diagnosis of pituicytoma is based on histopathological evidence. Pituicytomas consist of a solid proliferation of elongated spindle cells arranged in interlacing fascicles and/or in a “storiform” pattern. In immunohistochemical studies, pituicytomas was strongly expressed in TTF-1. CONCLUSION: Pituicytomas are benign, slow-growing glial tumors. It is difficult to diagnosed before operation as its clinical presentations and imaging studies resemble those of non-functional pituitary adenomas. The best chance of successful treatment is gross total resection by the endoscopic approach or transcranial approach. Elsevier 2022-08-26 /pmc/articles/PMC9482998/ /pubmed/36057248 http://dx.doi.org/10.1016/j.ijscr.2022.107553 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Shen, Chia-Fang
Liu, Szu-Yuan
Lee, Chung-Hsin
Pan, Szu-Yen
Shen, Chiung-Chyi
Pituicytoma: A rare case report of sellar and suprasellar tumor
title Pituicytoma: A rare case report of sellar and suprasellar tumor
title_full Pituicytoma: A rare case report of sellar and suprasellar tumor
title_fullStr Pituicytoma: A rare case report of sellar and suprasellar tumor
title_full_unstemmed Pituicytoma: A rare case report of sellar and suprasellar tumor
title_short Pituicytoma: A rare case report of sellar and suprasellar tumor
title_sort pituicytoma: a rare case report of sellar and suprasellar tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9482998/
https://www.ncbi.nlm.nih.gov/pubmed/36057248
http://dx.doi.org/10.1016/j.ijscr.2022.107553
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