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Research Progress on Exosomes in Osteonecrosis of the Femoral Head

Osteonecrosis of the femoral head (ONFH) is a progressive disease that often necessitates hip replacement if hip preservation therapy fails. ONFH places a heavy economic burden and severe psychological pressure on patients. At present, ONFH is treated by either surgical or non‐surgical methods. In c...

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Autores principales: Liu, Xiuzhi, Wang, Cheng, Meng, Haoye, Liao, Sida, Zhang, Jian, Guan, Yanjun, Tian, Hua, Peng, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: ohn Wiley & Sons Australia, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483046/
https://www.ncbi.nlm.nih.gov/pubmed/35924692
http://dx.doi.org/10.1111/os.13393
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author Liu, Xiuzhi
Wang, Cheng
Meng, Haoye
Liao, Sida
Zhang, Jian
Guan, Yanjun
Tian, Hua
Peng, Jiang
author_facet Liu, Xiuzhi
Wang, Cheng
Meng, Haoye
Liao, Sida
Zhang, Jian
Guan, Yanjun
Tian, Hua
Peng, Jiang
author_sort Liu, Xiuzhi
collection PubMed
description Osteonecrosis of the femoral head (ONFH) is a progressive disease that often necessitates hip replacement if hip preservation therapy fails. ONFH places a heavy economic burden and severe psychological pressure on patients. At present, ONFH is treated by either surgical or non‐surgical methods. In clinical practice, stem cells combined with surgery has achieved some positive results, but many problems remain to be resolved. Exosomes are small vesicles of 30–150 nm, which are rich in various nucleic acids, proteins, and small molecules depending on the cells from which they are derived. A growing number of studies have found that exosomes play an important role in tissue damage repair. In comparison with stem cells, exosomes have lower immunogenicity. Also, exosomes can promote cell proliferation and inhibit tumor growth. In addition, exosomes can also be used as natural carriers of drugs. Many studies have shown that exosomes have therapeutic effects in hormone‐induced ONFH. Exosomes have the effect of promoting vascular regeneration and show good application prospects in ONFH. Here, we present a review of studies on the application of exosomes in ONFH to provide a reference for future research.
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spelling pubmed-94830462022-09-29 Research Progress on Exosomes in Osteonecrosis of the Femoral Head Liu, Xiuzhi Wang, Cheng Meng, Haoye Liao, Sida Zhang, Jian Guan, Yanjun Tian, Hua Peng, Jiang Orthop Surg Review Articles Osteonecrosis of the femoral head (ONFH) is a progressive disease that often necessitates hip replacement if hip preservation therapy fails. ONFH places a heavy economic burden and severe psychological pressure on patients. At present, ONFH is treated by either surgical or non‐surgical methods. In clinical practice, stem cells combined with surgery has achieved some positive results, but many problems remain to be resolved. Exosomes are small vesicles of 30–150 nm, which are rich in various nucleic acids, proteins, and small molecules depending on the cells from which they are derived. A growing number of studies have found that exosomes play an important role in tissue damage repair. In comparison with stem cells, exosomes have lower immunogenicity. Also, exosomes can promote cell proliferation and inhibit tumor growth. In addition, exosomes can also be used as natural carriers of drugs. Many studies have shown that exosomes have therapeutic effects in hormone‐induced ONFH. Exosomes have the effect of promoting vascular regeneration and show good application prospects in ONFH. Here, we present a review of studies on the application of exosomes in ONFH to provide a reference for future research. ohn Wiley & Sons Australia, Ltd 2022-08-04 /pmc/articles/PMC9483046/ /pubmed/35924692 http://dx.doi.org/10.1111/os.13393 Text en © 2022 The Authors. Orthopaedic Surgery published by Tianjin Hospital and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Liu, Xiuzhi
Wang, Cheng
Meng, Haoye
Liao, Sida
Zhang, Jian
Guan, Yanjun
Tian, Hua
Peng, Jiang
Research Progress on Exosomes in Osteonecrosis of the Femoral Head
title Research Progress on Exosomes in Osteonecrosis of the Femoral Head
title_full Research Progress on Exosomes in Osteonecrosis of the Femoral Head
title_fullStr Research Progress on Exosomes in Osteonecrosis of the Femoral Head
title_full_unstemmed Research Progress on Exosomes in Osteonecrosis of the Femoral Head
title_short Research Progress on Exosomes in Osteonecrosis of the Femoral Head
title_sort research progress on exosomes in osteonecrosis of the femoral head
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483046/
https://www.ncbi.nlm.nih.gov/pubmed/35924692
http://dx.doi.org/10.1111/os.13393
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