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Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database

BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcomas in children. This study aimed to investigate the prognostic factors of pelvic and genitourinary RMS in children and evaluate the survival outcomes of these children treated with or without radiation therapy (RT). METHODS: The...

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Autores principales: Wu, Jiheng, Shou, Xinyi, Cai, Jiabin, Mao, Junqing, Qian, Jianqin, Wang, Jinhu, Ni, Shaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483154/
https://www.ncbi.nlm.nih.gov/pubmed/36132132
http://dx.doi.org/10.3389/fonc.2022.992738
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author Wu, Jiheng
Shou, Xinyi
Cai, Jiabin
Mao, Junqing
Qian, Jianqin
Wang, Jinhu
Ni, Shaoqing
author_facet Wu, Jiheng
Shou, Xinyi
Cai, Jiabin
Mao, Junqing
Qian, Jianqin
Wang, Jinhu
Ni, Shaoqing
author_sort Wu, Jiheng
collection PubMed
description BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcomas in children. This study aimed to investigate the prognostic factors of pelvic and genitourinary RMS in children and evaluate the survival outcomes of these children treated with or without radiation therapy (RT). METHODS: The Surveillance, Epidemiology, and End Results Program (SEER) database was required for children with pelvic and genitourinary RMS. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Meier method, log-rank test, Cox proportional hazards models, and propensity score-matched analyses. RESULTS: For the 262 patients analyzed, the most common biological subtypes were embryonic (n=209, 79.8%) and alveolar (n=29, 11.1%). Patients with alveolar RMS had the worst prognosis (P < 0.05). The testis (n=122, 46.6%) was the most common location, followed by the urinary bladder (n=57, 21.8%) and prostate (n=48, 18.3%). Uterus RMS had the highest survival rate, followed by testis, urinary bladder, and prostate RMS. Favorable prognostic factors were age at diagnosis < 15 years, non-alveolar histological subtype, early tumor stage (localized/regional), specific sites (uterus and testis), and treatment (cancer-directed surgery and chemotherapy) (P < 0.05). Propensity score-matched analyses comparing the cohorts of patients treated with or without RT demonstrated no significant differences in prognostic survival (OS: P=0.872, CSS: P=0.713). CONCLUSION: The nomogram constructed based on independent prognostic factors may accurately predict survival rates at 1 and 5 years. Surgery and adjuvant chemotherapy can be effective treatments, but RT fails to guarantee a survival benefit. Therefore, prospective trials evaluating RT for pediatric pelvic and genitourinary RMS are warranted.
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spelling pubmed-94831542022-09-20 Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database Wu, Jiheng Shou, Xinyi Cai, Jiabin Mao, Junqing Qian, Jianqin Wang, Jinhu Ni, Shaoqing Front Oncol Oncology BACKGROUND: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcomas in children. This study aimed to investigate the prognostic factors of pelvic and genitourinary RMS in children and evaluate the survival outcomes of these children treated with or without radiation therapy (RT). METHODS: The Surveillance, Epidemiology, and End Results Program (SEER) database was required for children with pelvic and genitourinary RMS. Overall survival (OS) and cancer-specific survival (CSS) were analyzed using the Kaplan-Meier method, log-rank test, Cox proportional hazards models, and propensity score-matched analyses. RESULTS: For the 262 patients analyzed, the most common biological subtypes were embryonic (n=209, 79.8%) and alveolar (n=29, 11.1%). Patients with alveolar RMS had the worst prognosis (P < 0.05). The testis (n=122, 46.6%) was the most common location, followed by the urinary bladder (n=57, 21.8%) and prostate (n=48, 18.3%). Uterus RMS had the highest survival rate, followed by testis, urinary bladder, and prostate RMS. Favorable prognostic factors were age at diagnosis < 15 years, non-alveolar histological subtype, early tumor stage (localized/regional), specific sites (uterus and testis), and treatment (cancer-directed surgery and chemotherapy) (P < 0.05). Propensity score-matched analyses comparing the cohorts of patients treated with or without RT demonstrated no significant differences in prognostic survival (OS: P=0.872, CSS: P=0.713). CONCLUSION: The nomogram constructed based on independent prognostic factors may accurately predict survival rates at 1 and 5 years. Surgery and adjuvant chemotherapy can be effective treatments, but RT fails to guarantee a survival benefit. Therefore, prospective trials evaluating RT for pediatric pelvic and genitourinary RMS are warranted. Frontiers Media S.A. 2022-09-05 /pmc/articles/PMC9483154/ /pubmed/36132132 http://dx.doi.org/10.3389/fonc.2022.992738 Text en Copyright © 2022 Wu, Shou, Cai, Mao, Qian, Wang and Ni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Jiheng
Shou, Xinyi
Cai, Jiabin
Mao, Junqing
Qian, Jianqin
Wang, Jinhu
Ni, Shaoqing
Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database
title Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database
title_full Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database
title_fullStr Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database
title_full_unstemmed Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database
title_short Prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: An analysis based on SEER database
title_sort prognostic factors of pediatric pelvic and genitourinary rhabdomyosarcoma: an analysis based on seer database
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483154/
https://www.ncbi.nlm.nih.gov/pubmed/36132132
http://dx.doi.org/10.3389/fonc.2022.992738
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