Cargando…

Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up

PURPOSE: We aimed to investigate the possible effect of SARS-CoV-2 vaccination on sperm quality by evaluating semen analyses of men prior to vaccination and 6–14 months after vaccination. METHODS: This was a retrospective cohort study, conducted in a university-affiliated in vitro fertilization cent...

Descripción completa

Detalles Bibliográficos
Autores principales: Karavani, Gilad, Chill, Henry H., Meirman, Cherut, Gutman-Ido, Einat, Herzberg, Shmuel, Tzipora, Tachover, Imbar, Tal, Ben-Meir, Assaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483282/
https://www.ncbi.nlm.nih.gov/pubmed/36114906
http://dx.doi.org/10.1007/s10815-022-02621-x
_version_ 1784791638880550912
author Karavani, Gilad
Chill, Henry H.
Meirman, Cherut
Gutman-Ido, Einat
Herzberg, Shmuel
Tzipora, Tachover
Imbar, Tal
Ben-Meir, Assaf
author_facet Karavani, Gilad
Chill, Henry H.
Meirman, Cherut
Gutman-Ido, Einat
Herzberg, Shmuel
Tzipora, Tachover
Imbar, Tal
Ben-Meir, Assaf
author_sort Karavani, Gilad
collection PubMed
description PURPOSE: We aimed to investigate the possible effect of SARS-CoV-2 vaccination on sperm quality by evaluating semen analyses of men prior to vaccination and 6–14 months after vaccination. METHODS: This was a retrospective cohort study, conducted in a university-affiliated in vitro fertilization center between October 2021 and March 2022, including men not previously infected with the SARS-CoV-2 virus who received at least 2 doses of the Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccine. Semen analyses of samples given pre-vaccination and 6–14 months post-vaccination were analyzed for the parameters of volume, concentration, motility, morphology, and total motile count (TMC) and compared. These parameters were also compared separately for men who received a third (booster) dose and for men with pre-vaccination normal and abnormal sperm. Correlations between time from vaccination and post-vaccination sperm parameters were also assessed. RESULTS: Fifty-eight men were included in the final analysis. Semen volume (2.9 ± 1.4 vs. 2.9 ± 1.6 ml), sperm concentration (42.9 ± 37.9 vs. 51.5 ± 46.2 million/ml), motility (42.5 ± 23.1 vs. 44.3 ± 23.4 percent), morphology (8.8 ± .16.6 vs. 6.6 ± 8.8 percent), and TMC (55.7 ± 57.9 vs. 71.1 ± 77.1 million) were comparable between the pre- and post-vaccination samples. This was true for the entire study cohort, for the subgroup of men who received a third dose and for the subgroups of men with a pre-vaccination normal and abnormal semen samples. No correlation was found between time from vaccination and post-vaccination sperm parameters. CONCLUSIONS: The Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccine does not impair any of the sperm parameters over a relatively long-time interval of 6 to 14 months from vaccination. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10815-022-02621-x.
format Online
Article
Text
id pubmed-9483282
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer US
record_format MEDLINE/PubMed
spelling pubmed-94832822022-09-19 Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up Karavani, Gilad Chill, Henry H. Meirman, Cherut Gutman-Ido, Einat Herzberg, Shmuel Tzipora, Tachover Imbar, Tal Ben-Meir, Assaf J Assist Reprod Genet Gamete Biology PURPOSE: We aimed to investigate the possible effect of SARS-CoV-2 vaccination on sperm quality by evaluating semen analyses of men prior to vaccination and 6–14 months after vaccination. METHODS: This was a retrospective cohort study, conducted in a university-affiliated in vitro fertilization center between October 2021 and March 2022, including men not previously infected with the SARS-CoV-2 virus who received at least 2 doses of the Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccine. Semen analyses of samples given pre-vaccination and 6–14 months post-vaccination were analyzed for the parameters of volume, concentration, motility, morphology, and total motile count (TMC) and compared. These parameters were also compared separately for men who received a third (booster) dose and for men with pre-vaccination normal and abnormal sperm. Correlations between time from vaccination and post-vaccination sperm parameters were also assessed. RESULTS: Fifty-eight men were included in the final analysis. Semen volume (2.9 ± 1.4 vs. 2.9 ± 1.6 ml), sperm concentration (42.9 ± 37.9 vs. 51.5 ± 46.2 million/ml), motility (42.5 ± 23.1 vs. 44.3 ± 23.4 percent), morphology (8.8 ± .16.6 vs. 6.6 ± 8.8 percent), and TMC (55.7 ± 57.9 vs. 71.1 ± 77.1 million) were comparable between the pre- and post-vaccination samples. This was true for the entire study cohort, for the subgroup of men who received a third dose and for the subgroups of men with a pre-vaccination normal and abnormal semen samples. No correlation was found between time from vaccination and post-vaccination sperm parameters. CONCLUSIONS: The Pfizer-BioNTech (BNT162b2) SARS-CoV-2 vaccine does not impair any of the sperm parameters over a relatively long-time interval of 6 to 14 months from vaccination. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10815-022-02621-x. Springer US 2022-09-17 2022-10 /pmc/articles/PMC9483282/ /pubmed/36114906 http://dx.doi.org/10.1007/s10815-022-02621-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
spellingShingle Gamete Biology
Karavani, Gilad
Chill, Henry H.
Meirman, Cherut
Gutman-Ido, Einat
Herzberg, Shmuel
Tzipora, Tachover
Imbar, Tal
Ben-Meir, Assaf
Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up
title Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up
title_full Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up
title_fullStr Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up
title_full_unstemmed Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up
title_short Sperm quality is not affected by the BNT162b2 mRNA SARS-CoV-2 vaccine: results of a 6–14 months follow-up
title_sort sperm quality is not affected by the bnt162b2 mrna sars-cov-2 vaccine: results of a 6–14 months follow-up
topic Gamete Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483282/
https://www.ncbi.nlm.nih.gov/pubmed/36114906
http://dx.doi.org/10.1007/s10815-022-02621-x
work_keys_str_mv AT karavanigilad spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT chillhenryh spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT meirmancherut spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT gutmanidoeinat spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT herzbergshmuel spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT tziporatachover spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT imbartal spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup
AT benmeirassaf spermqualityisnotaffectedbythebnt162b2mrnasarscov2vaccineresultsofa614monthsfollowup