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Long-Term Antibody Response to SARS-CoV-2 in Children
Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation of Latent Disease) Study is a prospective cohort study design...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483535/ https://www.ncbi.nlm.nih.gov/pubmed/36121535 http://dx.doi.org/10.1007/s10875-022-01355-w |
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author | Dunay, Gabor A. Barroso, Madalena Woidy, Mathias Danecka, Marta K. Engels, Geraldine Hermann, Katharina Neumann, Friederike S. Paul, Kevin Beime, Jan Escherich, Gabriele Fehse, Kristin Grinstein, Lev Haniel, Franziska Haupt, Luka J. Hecher, Laura Kehl, Torben Kemen, Christoph Kemper, Markus J. Kobbe, Robin Kohl, Aloisa Klokow, Thomas Nörz, Dominik Olfe, Jakob Schlenker, Friderike Schmiesing, Jessica Schrum, Johanna Sibbertsen, Freya Stock, Philippe Tiede, Stephan Vettorazzi, Eik Zazara, Dimitra E. Zapf, Antonia Lütgehetmann, Marc Oh, Jun Mir, Thomas S. Muntau, Ania C. Gersting, Søren W. |
author_facet | Dunay, Gabor A. Barroso, Madalena Woidy, Mathias Danecka, Marta K. Engels, Geraldine Hermann, Katharina Neumann, Friederike S. Paul, Kevin Beime, Jan Escherich, Gabriele Fehse, Kristin Grinstein, Lev Haniel, Franziska Haupt, Luka J. Hecher, Laura Kehl, Torben Kemen, Christoph Kemper, Markus J. Kobbe, Robin Kohl, Aloisa Klokow, Thomas Nörz, Dominik Olfe, Jakob Schlenker, Friderike Schmiesing, Jessica Schrum, Johanna Sibbertsen, Freya Stock, Philippe Tiede, Stephan Vettorazzi, Eik Zazara, Dimitra E. Zapf, Antonia Lütgehetmann, Marc Oh, Jun Mir, Thomas S. Muntau, Ania C. Gersting, Søren W. |
author_sort | Dunay, Gabor A. |
collection | PubMed |
description | Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation of Latent Disease) Study is a prospective cohort study designed to identify and follow up children and their household contacts infected in the early 2020 first wave of SARS-CoV-2. We screened 6113 children < 18 years by nasopharyngeal swab-PCR in a low-incidence setting after general lockdown, from May 11 to June 30, 2020. A total of 4657 participants underwent antibody testing. Positive tests were followed up by repeated PCR and serological testing of all household contacts over 6 months. In total, the study identified 67 seropositive children (1.44%); the median time after infection at first presentation was 83 days post-symptom onset (PSO). Follow-up of household contacts showed less than 100% seroprevalence in most families, with higher seroprevalence in families with adult index cases compared to pediatric index cases (OR 1.79, P = 0.047). Most importantly, children showed sustained seroconversion up to 9 months PSO, and serum antibody concentrations persistently surpassed adult levels (ratio serum IgG spike children vs. adults 90 days PSO 1.75, P < 0.001; 180 days 1.38, P = 0.01; 270 days 1.54, P = 0.001). In a low-incidence setting, SARS-CoV-2 infection and humoral immune response present distinct patterns in children including higher antibody levels, and lower seroprevalence in families with pediatric index cases. Children show long-term SARS-CoV-2 antibody responses. These findings are relevant to novel variants with increased disease burden in children, as well as for the planning of age-appropriate vaccination strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10875-022-01355-w. |
format | Online Article Text |
id | pubmed-9483535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-94835352022-09-19 Long-Term Antibody Response to SARS-CoV-2 in Children Dunay, Gabor A. Barroso, Madalena Woidy, Mathias Danecka, Marta K. Engels, Geraldine Hermann, Katharina Neumann, Friederike S. Paul, Kevin Beime, Jan Escherich, Gabriele Fehse, Kristin Grinstein, Lev Haniel, Franziska Haupt, Luka J. Hecher, Laura Kehl, Torben Kemen, Christoph Kemper, Markus J. Kobbe, Robin Kohl, Aloisa Klokow, Thomas Nörz, Dominik Olfe, Jakob Schlenker, Friderike Schmiesing, Jessica Schrum, Johanna Sibbertsen, Freya Stock, Philippe Tiede, Stephan Vettorazzi, Eik Zazara, Dimitra E. Zapf, Antonia Lütgehetmann, Marc Oh, Jun Mir, Thomas S. Muntau, Ania C. Gersting, Søren W. J Clin Immunol Original Article Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID-19 Child Health Investigation of Latent Disease) Study is a prospective cohort study designed to identify and follow up children and their household contacts infected in the early 2020 first wave of SARS-CoV-2. We screened 6113 children < 18 years by nasopharyngeal swab-PCR in a low-incidence setting after general lockdown, from May 11 to June 30, 2020. A total of 4657 participants underwent antibody testing. Positive tests were followed up by repeated PCR and serological testing of all household contacts over 6 months. In total, the study identified 67 seropositive children (1.44%); the median time after infection at first presentation was 83 days post-symptom onset (PSO). Follow-up of household contacts showed less than 100% seroprevalence in most families, with higher seroprevalence in families with adult index cases compared to pediatric index cases (OR 1.79, P = 0.047). Most importantly, children showed sustained seroconversion up to 9 months PSO, and serum antibody concentrations persistently surpassed adult levels (ratio serum IgG spike children vs. adults 90 days PSO 1.75, P < 0.001; 180 days 1.38, P = 0.01; 270 days 1.54, P = 0.001). In a low-incidence setting, SARS-CoV-2 infection and humoral immune response present distinct patterns in children including higher antibody levels, and lower seroprevalence in families with pediatric index cases. Children show long-term SARS-CoV-2 antibody responses. These findings are relevant to novel variants with increased disease burden in children, as well as for the planning of age-appropriate vaccination strategies. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10875-022-01355-w. Springer US 2022-09-19 2023 /pmc/articles/PMC9483535/ /pubmed/36121535 http://dx.doi.org/10.1007/s10875-022-01355-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Dunay, Gabor A. Barroso, Madalena Woidy, Mathias Danecka, Marta K. Engels, Geraldine Hermann, Katharina Neumann, Friederike S. Paul, Kevin Beime, Jan Escherich, Gabriele Fehse, Kristin Grinstein, Lev Haniel, Franziska Haupt, Luka J. Hecher, Laura Kehl, Torben Kemen, Christoph Kemper, Markus J. Kobbe, Robin Kohl, Aloisa Klokow, Thomas Nörz, Dominik Olfe, Jakob Schlenker, Friderike Schmiesing, Jessica Schrum, Johanna Sibbertsen, Freya Stock, Philippe Tiede, Stephan Vettorazzi, Eik Zazara, Dimitra E. Zapf, Antonia Lütgehetmann, Marc Oh, Jun Mir, Thomas S. Muntau, Ania C. Gersting, Søren W. Long-Term Antibody Response to SARS-CoV-2 in Children |
title | Long-Term Antibody Response to SARS-CoV-2 in Children |
title_full | Long-Term Antibody Response to SARS-CoV-2 in Children |
title_fullStr | Long-Term Antibody Response to SARS-CoV-2 in Children |
title_full_unstemmed | Long-Term Antibody Response to SARS-CoV-2 in Children |
title_short | Long-Term Antibody Response to SARS-CoV-2 in Children |
title_sort | long-term antibody response to sars-cov-2 in children |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483535/ https://www.ncbi.nlm.nih.gov/pubmed/36121535 http://dx.doi.org/10.1007/s10875-022-01355-w |
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