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Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change

Integrin α5β1 mediates cell adhesion to the extracellular matrix by binding fibronectin (Fn). Selectivity for Fn by α5β1 is achieved through recognition of an RGD motif in the 10th type III Fn domain (Fn10) and the synergy site in the ninth type III Fn domain (Fn9). However, details of the interacti...

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Detalles Bibliográficos
Autores principales:	Su, Yang, Iacob, Roxana E., Li, Jing, Engen, John R., Springer, Timothy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483561/ https://www.ncbi.nlm.nih.gov/pubmed/35931112 http://dx.doi.org/10.1016/j.jbc.2022.102323

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