Biomarkers in oral immunotherapy

Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcom...

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Detalles Bibliográficos
Autores principales: ZHU, Haitao, TANG, Kaifa, CHEN, Guoqiang, LIU, Zhongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Zhejiang University Press 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483607/
https://www.ncbi.nlm.nih.gov/pubmed/36111569
http://dx.doi.org/10.1631/jzus.B2200047
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author ZHU, Haitao
TANG, Kaifa
CHEN, Guoqiang
LIU, Zhongwei
author_facet ZHU, Haitao
TANG, Kaifa
CHEN, Guoqiang
LIU, Zhongwei
author_sort ZHU, Haitao
collection PubMed
description Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.
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spelling pubmed-94836072022-09-26 Biomarkers in oral immunotherapy ZHU, Haitao TANG, Kaifa CHEN, Guoqiang LIU, Zhongwei J Zhejiang Univ Sci B Review Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT. Zhejiang University Press 2022-09-15 /pmc/articles/PMC9483607/ /pubmed/36111569 http://dx.doi.org/10.1631/jzus.B2200047 Text en © Zhejiang University Press 2022
spellingShingle Review
ZHU, Haitao
TANG, Kaifa
CHEN, Guoqiang
LIU, Zhongwei
Biomarkers in oral immunotherapy
title Biomarkers in oral immunotherapy
title_full Biomarkers in oral immunotherapy
title_fullStr Biomarkers in oral immunotherapy
title_full_unstemmed Biomarkers in oral immunotherapy
title_short Biomarkers in oral immunotherapy
title_sort biomarkers in oral immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483607/
https://www.ncbi.nlm.nih.gov/pubmed/36111569
http://dx.doi.org/10.1631/jzus.B2200047
work_keys_str_mv AT zhuhaitao biomarkersinoralimmunotherapy
AT tangkaifa biomarkersinoralimmunotherapy
AT chenguoqiang biomarkersinoralimmunotherapy
AT liuzhongwei biomarkersinoralimmunotherapy

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