Human eukaryotic initiation factor 4E (eIF4E) and the nucleotide-bound state of eIF4A regulate eIF4F binding to RNA

During translation initiation, the underlying mechanism by which the eukaryotic initiation factor (eIF) 4E, eIF4A, and eIF4G components of eIF4F coordinate their binding activities to regulate eIF4F binding to mRNA is poorly defined. Here, we used fluorescence anisotropy to generate thermodynamic an...

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Detalles Bibliográficos
Autores principales: Izidoro, Mario Servulo, Sokabe, Masaaki, Villa, Nancy, Merrick, William C., Fraser, Christopher S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483636/
https://www.ncbi.nlm.nih.gov/pubmed/35963437
http://dx.doi.org/10.1016/j.jbc.2022.102368

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