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Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs, such as poor localization at the tumor site, high drug doses and toxicity...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483748/ https://www.ncbi.nlm.nih.gov/pubmed/36185736 http://dx.doi.org/10.1016/j.bioactmat.2022.08.016 |
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author | Singh, Nem Kim, Jungryun Kim, Jaewon Lee, Kyungwoo Zunbul, Zehra Lee, Injun Kim, Eunji Chi, Sung-Gil Kim, Jong Seung |
author_facet | Singh, Nem Kim, Jungryun Kim, Jaewon Lee, Kyungwoo Zunbul, Zehra Lee, Injun Kim, Eunji Chi, Sung-Gil Kim, Jong Seung |
author_sort | Singh, Nem |
collection | PubMed |
description | Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs, such as poor localization at the tumor site, high drug doses and toxicity, recurrence, and poor immune response. However, inadequate biocompatibility restricts their potential in clinical translation. Therefore, advanced nanomaterials with high biocompatibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines. Intrinsic properties of nanoscale covalent organic frameworks (nCOFs), such as suitable size, modular pore geometry and porosity, and straightforward post-synthetic modification via simple organic transformations, make them incredibly attractive for future nanomedicines. The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery. This review summarizes recently published applications of COFs in drug delivery, photo-immuno therapy, sonodynamic therapy, photothermal therapy, chemotherapy, pyroptosis, and combination therapy. Herein we mainly focused on modifications of COFs to enhance their biocompatibility, efficacy and potential clinical translation. This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nanomedicines and will help in the rapid development of cancer drug carriers and theranostics. |
format | Online Article Text |
id | pubmed-9483748 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-94837482022-09-30 Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications Singh, Nem Kim, Jungryun Kim, Jaewon Lee, Kyungwoo Zunbul, Zehra Lee, Injun Kim, Eunji Chi, Sung-Gil Kim, Jong Seung Bioact Mater Review Article Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs, such as poor localization at the tumor site, high drug doses and toxicity, recurrence, and poor immune response. However, inadequate biocompatibility restricts their potential in clinical translation. Therefore, advanced nanomaterials with high biocompatibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines. Intrinsic properties of nanoscale covalent organic frameworks (nCOFs), such as suitable size, modular pore geometry and porosity, and straightforward post-synthetic modification via simple organic transformations, make them incredibly attractive for future nanomedicines. The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery. This review summarizes recently published applications of COFs in drug delivery, photo-immuno therapy, sonodynamic therapy, photothermal therapy, chemotherapy, pyroptosis, and combination therapy. Herein we mainly focused on modifications of COFs to enhance their biocompatibility, efficacy and potential clinical translation. This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nanomedicines and will help in the rapid development of cancer drug carriers and theranostics. KeAi Publishing 2022-09-14 /pmc/articles/PMC9483748/ /pubmed/36185736 http://dx.doi.org/10.1016/j.bioactmat.2022.08.016 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Article Singh, Nem Kim, Jungryun Kim, Jaewon Lee, Kyungwoo Zunbul, Zehra Lee, Injun Kim, Eunji Chi, Sung-Gil Kim, Jong Seung Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications |
title | Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications |
title_full | Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications |
title_fullStr | Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications |
title_full_unstemmed | Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications |
title_short | Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications |
title_sort | covalent organic framework nanomedicines: biocompatibility for advanced nanocarriers and cancer theranostics applications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483748/ https://www.ncbi.nlm.nih.gov/pubmed/36185736 http://dx.doi.org/10.1016/j.bioactmat.2022.08.016 |
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