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Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs, such as poor localization at the tumor site, high drug doses and toxicity...

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Autores principales: Singh, Nem, Kim, Jungryun, Kim, Jaewon, Lee, Kyungwoo, Zunbul, Zehra, Lee, Injun, Kim, Eunji, Chi, Sung-Gil, Kim, Jong Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483748/
https://www.ncbi.nlm.nih.gov/pubmed/36185736
http://dx.doi.org/10.1016/j.bioactmat.2022.08.016
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author Singh, Nem
Kim, Jungryun
Kim, Jaewon
Lee, Kyungwoo
Zunbul, Zehra
Lee, Injun
Kim, Eunji
Chi, Sung-Gil
Kim, Jong Seung
author_facet Singh, Nem
Kim, Jungryun
Kim, Jaewon
Lee, Kyungwoo
Zunbul, Zehra
Lee, Injun
Kim, Eunji
Chi, Sung-Gil
Kim, Jong Seung
author_sort Singh, Nem
collection PubMed
description Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs, such as poor localization at the tumor site, high drug doses and toxicity, recurrence, and poor immune response. However, inadequate biocompatibility restricts their potential in clinical translation. Therefore, advanced nanomaterials with high biocompatibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines. Intrinsic properties of nanoscale covalent organic frameworks (nCOFs), such as suitable size, modular pore geometry and porosity, and straightforward post-synthetic modification via simple organic transformations, make them incredibly attractive for future nanomedicines. The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery. This review summarizes recently published applications of COFs in drug delivery, photo-immuno therapy, sonodynamic therapy, photothermal therapy, chemotherapy, pyroptosis, and combination therapy. Herein we mainly focused on modifications of COFs to enhance their biocompatibility, efficacy and potential clinical translation. This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nanomedicines and will help in the rapid development of cancer drug carriers and theranostics.
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spelling pubmed-94837482022-09-30 Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications Singh, Nem Kim, Jungryun Kim, Jaewon Lee, Kyungwoo Zunbul, Zehra Lee, Injun Kim, Eunji Chi, Sung-Gil Kim, Jong Seung Bioact Mater Review Article Nanomedicines for drug delivery and imaging-guided cancer therapy is a rapidly growing research area. The unique properties of nanomedicines have a massive potential in solving longstanding challenges of existing cancer drugs, such as poor localization at the tumor site, high drug doses and toxicity, recurrence, and poor immune response. However, inadequate biocompatibility restricts their potential in clinical translation. Therefore, advanced nanomaterials with high biocompatibility and enhanced therapeutic efficiency are highly desired to fast-track the clinical translation of nanomedicines. Intrinsic properties of nanoscale covalent organic frameworks (nCOFs), such as suitable size, modular pore geometry and porosity, and straightforward post-synthetic modification via simple organic transformations, make them incredibly attractive for future nanomedicines. The ability of COFs to disintegrate in a slightly acidic tumor microenvironment also gives them a competitive advantage in targeted delivery. This review summarizes recently published applications of COFs in drug delivery, photo-immuno therapy, sonodynamic therapy, photothermal therapy, chemotherapy, pyroptosis, and combination therapy. Herein we mainly focused on modifications of COFs to enhance their biocompatibility, efficacy and potential clinical translation. This review will provide the fundamental knowledge in designing biocompatible nCOFs-based nanomedicines and will help in the rapid development of cancer drug carriers and theranostics. KeAi Publishing 2022-09-14 /pmc/articles/PMC9483748/ /pubmed/36185736 http://dx.doi.org/10.1016/j.bioactmat.2022.08.016 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review Article
Singh, Nem
Kim, Jungryun
Kim, Jaewon
Lee, Kyungwoo
Zunbul, Zehra
Lee, Injun
Kim, Eunji
Chi, Sung-Gil
Kim, Jong Seung
Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
title Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
title_full Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
title_fullStr Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
title_full_unstemmed Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
title_short Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications
title_sort covalent organic framework nanomedicines: biocompatibility for advanced nanocarriers and cancer theranostics applications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483748/
https://www.ncbi.nlm.nih.gov/pubmed/36185736
http://dx.doi.org/10.1016/j.bioactmat.2022.08.016
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