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White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD

OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patien...

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Autores principales: Byun, Jung-Ick, Oh, Seunghwan, Sunwoo, Jun-Sang, Shin, Jung-Won, Kim, Tae-Joon, Jun, Jin-Sun, Kim, Han-Joon, Shin, Won Chul, Seong, Joon-Kyung, Jung, Ki-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483791/
https://www.ncbi.nlm.nih.gov/pubmed/36116164
http://dx.doi.org/10.1016/j.nicl.2022.103186
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author Byun, Jung-Ick
Oh, Seunghwan
Sunwoo, Jun-Sang
Shin, Jung-Won
Kim, Tae-Joon
Jun, Jin-Sun
Kim, Han-Joon
Shin, Won Chul
Seong, Joon-Kyung
Jung, Ki-Young
author_facet Byun, Jung-Ick
Oh, Seunghwan
Sunwoo, Jun-Sang
Shin, Jung-Won
Kim, Tae-Joon
Jun, Jin-Sun
Kim, Han-Joon
Shin, Won Chul
Seong, Joon-Kyung
Jung, Ki-Young
author_sort Byun, Jung-Ick
collection PubMed
description OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patients. METHODS: This was a cross-sectional single-center study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used TSSA to identify tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in fourteen major fiber tracts and analyzed between-group differences in these values. Correlations between FA or MD values and clinical variables, including RBD symptom severity, depression and cognition, were evaluated. RESULTS: Patients with iRBD showed lower FA in the right anterior thalamic radiation (ATR) and higher MD in the bilateral ATR and right inferior fronto-occipital fasciculus (IF-OF) than controls after adjusting for age, sex, and years of education. MD values in the IF-OF positively correlated with scores on the Korean version of the Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-KR, p = 0.042) and the Korean version of the geriatric depression scale (GDS-K, p = 0.002) in iRBD patients. Only GDS-K scores independently correlated with IF-OF MD values after adjusting for RBDQ-KR scores (adjusted p = 0.026). CONCLUSION: This study suggests WM microstructural disruption in the bilateral ATR and right IF-OF in patients with iRBD and that alterations in the IF-OF may contribute to depressive symptoms.
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spelling pubmed-94837912022-09-20 White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD Byun, Jung-Ick Oh, Seunghwan Sunwoo, Jun-Sang Shin, Jung-Won Kim, Tae-Joon Jun, Jin-Sun Kim, Han-Joon Shin, Won Chul Seong, Joon-Kyung Jung, Ki-Young Neuroimage Clin Regular Article OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patients. METHODS: This was a cross-sectional single-center study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used TSSA to identify tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in fourteen major fiber tracts and analyzed between-group differences in these values. Correlations between FA or MD values and clinical variables, including RBD symptom severity, depression and cognition, were evaluated. RESULTS: Patients with iRBD showed lower FA in the right anterior thalamic radiation (ATR) and higher MD in the bilateral ATR and right inferior fronto-occipital fasciculus (IF-OF) than controls after adjusting for age, sex, and years of education. MD values in the IF-OF positively correlated with scores on the Korean version of the Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-KR, p = 0.042) and the Korean version of the geriatric depression scale (GDS-K, p = 0.002) in iRBD patients. Only GDS-K scores independently correlated with IF-OF MD values after adjusting for RBDQ-KR scores (adjusted p = 0.026). CONCLUSION: This study suggests WM microstructural disruption in the bilateral ATR and right IF-OF in patients with iRBD and that alterations in the IF-OF may contribute to depressive symptoms. Elsevier 2022-09-07 /pmc/articles/PMC9483791/ /pubmed/36116164 http://dx.doi.org/10.1016/j.nicl.2022.103186 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Byun, Jung-Ick
Oh, Seunghwan
Sunwoo, Jun-Sang
Shin, Jung-Won
Kim, Tae-Joon
Jun, Jin-Sun
Kim, Han-Joon
Shin, Won Chul
Seong, Joon-Kyung
Jung, Ki-Young
White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
title White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
title_full White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
title_fullStr White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
title_full_unstemmed White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
title_short White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
title_sort white matter tract-specific microstructural disruption is associated with depressive symptoms in isolated rbd
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483791/
https://www.ncbi.nlm.nih.gov/pubmed/36116164
http://dx.doi.org/10.1016/j.nicl.2022.103186
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