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White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD
OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patien...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483791/ https://www.ncbi.nlm.nih.gov/pubmed/36116164 http://dx.doi.org/10.1016/j.nicl.2022.103186 |
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author | Byun, Jung-Ick Oh, Seunghwan Sunwoo, Jun-Sang Shin, Jung-Won Kim, Tae-Joon Jun, Jin-Sun Kim, Han-Joon Shin, Won Chul Seong, Joon-Kyung Jung, Ki-Young |
author_facet | Byun, Jung-Ick Oh, Seunghwan Sunwoo, Jun-Sang Shin, Jung-Won Kim, Tae-Joon Jun, Jin-Sun Kim, Han-Joon Shin, Won Chul Seong, Joon-Kyung Jung, Ki-Young |
author_sort | Byun, Jung-Ick |
collection | PubMed |
description | OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patients. METHODS: This was a cross-sectional single-center study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used TSSA to identify tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in fourteen major fiber tracts and analyzed between-group differences in these values. Correlations between FA or MD values and clinical variables, including RBD symptom severity, depression and cognition, were evaluated. RESULTS: Patients with iRBD showed lower FA in the right anterior thalamic radiation (ATR) and higher MD in the bilateral ATR and right inferior fronto-occipital fasciculus (IF-OF) than controls after adjusting for age, sex, and years of education. MD values in the IF-OF positively correlated with scores on the Korean version of the Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-KR, p = 0.042) and the Korean version of the geriatric depression scale (GDS-K, p = 0.002) in iRBD patients. Only GDS-K scores independently correlated with IF-OF MD values after adjusting for RBDQ-KR scores (adjusted p = 0.026). CONCLUSION: This study suggests WM microstructural disruption in the bilateral ATR and right IF-OF in patients with iRBD and that alterations in the IF-OF may contribute to depressive symptoms. |
format | Online Article Text |
id | pubmed-9483791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94837912022-09-20 White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD Byun, Jung-Ick Oh, Seunghwan Sunwoo, Jun-Sang Shin, Jung-Won Kim, Tae-Joon Jun, Jin-Sun Kim, Han-Joon Shin, Won Chul Seong, Joon-Kyung Jung, Ki-Young Neuroimage Clin Regular Article OBJECTIVE: White matter (WM) tract-specific changes may precede gray matter loss in isolated rapid eye movement sleep behavior disorder (iRBD). We aimed to evaluate tract-specific WM changes using tract-specific statistical analysis (TSSA) and their correlation with clinical variables in iRBD patients. METHODS: This was a cross-sectional single-center study of 50 polysomnography-confirmed iRBD patients and 20 age- and sex-matched controls. We used TSSA to identify tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in fourteen major fiber tracts and analyzed between-group differences in these values. Correlations between FA or MD values and clinical variables, including RBD symptom severity, depression and cognition, were evaluated. RESULTS: Patients with iRBD showed lower FA in the right anterior thalamic radiation (ATR) and higher MD in the bilateral ATR and right inferior fronto-occipital fasciculus (IF-OF) than controls after adjusting for age, sex, and years of education. MD values in the IF-OF positively correlated with scores on the Korean version of the Rapid Eye Movement Sleep Behavior Disorder Questionnaire-Hong Kong (RBDQ-KR, p = 0.042) and the Korean version of the geriatric depression scale (GDS-K, p = 0.002) in iRBD patients. Only GDS-K scores independently correlated with IF-OF MD values after adjusting for RBDQ-KR scores (adjusted p = 0.026). CONCLUSION: This study suggests WM microstructural disruption in the bilateral ATR and right IF-OF in patients with iRBD and that alterations in the IF-OF may contribute to depressive symptoms. Elsevier 2022-09-07 /pmc/articles/PMC9483791/ /pubmed/36116164 http://dx.doi.org/10.1016/j.nicl.2022.103186 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Byun, Jung-Ick Oh, Seunghwan Sunwoo, Jun-Sang Shin, Jung-Won Kim, Tae-Joon Jun, Jin-Sun Kim, Han-Joon Shin, Won Chul Seong, Joon-Kyung Jung, Ki-Young White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
title | White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
title_full | White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
title_fullStr | White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
title_full_unstemmed | White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
title_short | White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD |
title_sort | white matter tract-specific microstructural disruption is associated with depressive symptoms in isolated rbd |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483791/ https://www.ncbi.nlm.nih.gov/pubmed/36116164 http://dx.doi.org/10.1016/j.nicl.2022.103186 |
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