Thrombospondin-1 overexpression stimulates loss of Smad4 and accelerates malignant behavior via TGF-β signal activation in pancreatic ductal adenocarcinoma

INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma and cancer-associated fibroblasts (CAFs) provide a favorable tumor microenvironment. Smad4 is known as tumor suppressor in several types of cancers including PDAC, and loss of Smad4 triggers accelerated cell in...

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Detalles Bibliográficos
Autores principales: Matsumura, Kazuki, Hayashi, Hiromitsu, Uemura, Norio, Ogata, Yoko, Zhao, Liu, Sato, Hiroki, Shiraishi, Yuta, Kuroki, Hideyuki, Kitamura, Fumimasa, Kaida, Takayoshi, Higashi, Takaaki, Nakagawa, Shigeki, Mima, Kosuke, Imai, Katsunori, Yamashita, Yo-ichi, Baba, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483797/
https://www.ncbi.nlm.nih.gov/pubmed/36115074
http://dx.doi.org/10.1016/j.tranon.2022.101533

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