PAD4-dependent citrullination of nuclear translocation of GSK3β promotes colorectal cancer progression via the degradation of nuclear CDKN1A

Peptidylarginine deiminase 4 (PAD4), a Ca(2+)-dependent enzyme, catalyzes the conversion of arginine to citrulline and has been strongly associated with many malignant tumors. However, the molecular mechanisms of PAD4 in the development and progression of colorectal cancer (CRC) remain unclearly def...

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Detalles Bibliográficos
Autores principales: Luo, Xiaonuan, Chang, Shanshan, Xiao, Siyu, Peng, Yin, Gao, Yuli, Hu, Fan, Liang, Jianxue, Xu, Yidan, Du, Kaining, Chen, Yang, Qin, Jiequan, Meltzer, Stephen J., Deng, Shiqi, Feng, Xianling, Fan, Xinmin, Hou, Gangqiang, Jin, Zhe, Zhang, Xiaojing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483803/
https://www.ncbi.nlm.nih.gov/pubmed/36113195
http://dx.doi.org/10.1016/j.neo.2022.100835

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