Functional temozolomide sensitivity testing of patient-specific glioblastoma stem cell cultures is predictive of clinical outcome

Serum-free culturing of patient-derived glioblastoma biopsies enrich for glioblastoma stem cells (GSCs) and is recognized as a disease-relevant model system in glioblastoma (GBM). We hypothesized that the temozolomide (TMZ) drug sensitivity of patient-derived GSC cultures correlates to clinical sens...

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Detalles Bibliográficos
Autores principales: Skaga, Erlend, Kulesskiy, Evgeny, Potdar, Swapnil, Panagopoulos, Ioannis, Micci, Francesca, Langmoen, Iver A., Sandberg, Cecilie J., Vik-Mo, Einar O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483808/
https://www.ncbi.nlm.nih.gov/pubmed/36115076
http://dx.doi.org/10.1016/j.tranon.2022.101535

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