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Frustration and the Kinetic Repartitioning Mechanism of Substrate Inhibition in Enzyme Catalysis

[Image: see text] Substrate inhibition, whereby enzymatic activity decreases with excess substrate after reaching a maximum turnover rate, is among the most elusive phenomena in enzymatic catalysis. Here, based on a dynamic energy landscape model, we investigate the underlying mechanism by performin...

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Detalles Bibliográficos
Autores principales:	Zhang, Yangyang, Chen, Mingchen, Lu, Jiajun, Li, Wenfei, Wolynes, Peter G., Wang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483917/ https://www.ncbi.nlm.nih.gov/pubmed/36044985 http://dx.doi.org/10.1021/acs.jpcb.2c03832

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