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A fatal case of chlorfenapyr poisoning and a review of the literature

BACKGROUND: Chlorfenapyr is a widely used pesticide and is classified as moderately hazardous to human health. Ingestion usually leads to mortality in humans. However, chlorfenapyr toxicity has a variable course and mechanism of action. Case presentation: We report the case of a 79-year-old female w...

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Autores principales: Chien, Shih-Chun, Chien, Shih-Chao, Su, Yu-Jang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483958/
https://www.ncbi.nlm.nih.gov/pubmed/36112969
http://dx.doi.org/10.1177/03000605221121965
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author Chien, Shih-Chun
Chien, Shih-Chao
Su, Yu-Jang
author_facet Chien, Shih-Chun
Chien, Shih-Chao
Su, Yu-Jang
author_sort Chien, Shih-Chun
collection PubMed
description BACKGROUND: Chlorfenapyr is a widely used pesticide and is classified as moderately hazardous to human health. Ingestion usually leads to mortality in humans. However, chlorfenapyr toxicity has a variable course and mechanism of action. Case presentation: We report the case of a 79-year-old female who ingested chlorfenapyr with the intent to commit suicide. The liquid was ingested 2 hours before she was brought to our emergency department. Gastric lavage was immediately performed. On admission, laboratory examinations revealed mildly elevated liver enzyme and creatinine kinase levels. Acute fever occurred on day 7; on day 8, the patient died of progressive respiratory distress and conscious disturbance. Chlorfenapyr toxicity leads to high rates of mortality (75%) and causes damage to the liver and the nervous system. CONCLUSIONS: It is necessary to observe patients with chlorfenapyr toxicity for 3 weeks because no significant abnormalities occur in the early phase. The onset of fever and deterioration of consciousness is a warning sign of a sudden fatal outcome. We review the literature and discuss neurologic and cardiopulmonary impairment in the clinical course of chlorfenapyr poisoning.
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spelling pubmed-94839582022-09-20 A fatal case of chlorfenapyr poisoning and a review of the literature Chien, Shih-Chun Chien, Shih-Chao Su, Yu-Jang J Int Med Res Case Reports BACKGROUND: Chlorfenapyr is a widely used pesticide and is classified as moderately hazardous to human health. Ingestion usually leads to mortality in humans. However, chlorfenapyr toxicity has a variable course and mechanism of action. Case presentation: We report the case of a 79-year-old female who ingested chlorfenapyr with the intent to commit suicide. The liquid was ingested 2 hours before she was brought to our emergency department. Gastric lavage was immediately performed. On admission, laboratory examinations revealed mildly elevated liver enzyme and creatinine kinase levels. Acute fever occurred on day 7; on day 8, the patient died of progressive respiratory distress and conscious disturbance. Chlorfenapyr toxicity leads to high rates of mortality (75%) and causes damage to the liver and the nervous system. CONCLUSIONS: It is necessary to observe patients with chlorfenapyr toxicity for 3 weeks because no significant abnormalities occur in the early phase. The onset of fever and deterioration of consciousness is a warning sign of a sudden fatal outcome. We review the literature and discuss neurologic and cardiopulmonary impairment in the clinical course of chlorfenapyr poisoning. SAGE Publications 2022-09-16 /pmc/articles/PMC9483958/ /pubmed/36112969 http://dx.doi.org/10.1177/03000605221121965 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Chien, Shih-Chun
Chien, Shih-Chao
Su, Yu-Jang
A fatal case of chlorfenapyr poisoning and a review of the literature
title A fatal case of chlorfenapyr poisoning and a review of the literature
title_full A fatal case of chlorfenapyr poisoning and a review of the literature
title_fullStr A fatal case of chlorfenapyr poisoning and a review of the literature
title_full_unstemmed A fatal case of chlorfenapyr poisoning and a review of the literature
title_short A fatal case of chlorfenapyr poisoning and a review of the literature
title_sort fatal case of chlorfenapyr poisoning and a review of the literature
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9483958/
https://www.ncbi.nlm.nih.gov/pubmed/36112969
http://dx.doi.org/10.1177/03000605221121965
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