A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo

Two patients with longstanding vitiligo presented with repigmentation in sun-exposed areas as a previously unreported phenomenon coinciding with initiating loop diuretic therapy. Loop diuretics antagonize Na-K-Cl cotransporters and have been associated with a variety of cutaneous adverse effects, su...

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Detalles Bibliográficos
Autores principales: Arndt, Mary, Sennett, Rachel, Marsch, Amanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Dermatology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484005/
https://www.ncbi.nlm.nih.gov/pubmed/36159953
http://dx.doi.org/10.7759/cureus.16836
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author Arndt, Mary
Sennett, Rachel
Marsch, Amanda
author_facet Arndt, Mary
Sennett, Rachel
Marsch, Amanda
author_sort Arndt, Mary
collection PubMed
description Two patients with longstanding vitiligo presented with repigmentation in sun-exposed areas as a previously unreported phenomenon coinciding with initiating loop diuretic therapy. Loop diuretics antagonize Na-K-Cl cotransporters and have been associated with a variety of cutaneous adverse effects, such as bullous pemphigoid and photosensitivity, but have yet to be cited as drugs associated with vitiligo repigmentation. This report explores the direct and indirect influence loop diuretics may have on inducing pigmentation changes.
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spelling pubmed-94840052022-09-22 A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo Arndt, Mary Sennett, Rachel Marsch, Amanda Cureus Dermatology Two patients with longstanding vitiligo presented with repigmentation in sun-exposed areas as a previously unreported phenomenon coinciding with initiating loop diuretic therapy. Loop diuretics antagonize Na-K-Cl cotransporters and have been associated with a variety of cutaneous adverse effects, such as bullous pemphigoid and photosensitivity, but have yet to be cited as drugs associated with vitiligo repigmentation. This report explores the direct and indirect influence loop diuretics may have on inducing pigmentation changes. Cureus 2021-08-02 /pmc/articles/PMC9484005/ /pubmed/36159953 http://dx.doi.org/10.7759/cureus.16836 Text en Copyright © 2021, Arndt et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Dermatology
Arndt, Mary
Sennett, Rachel
Marsch, Amanda
A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo
title A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo
title_full A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo
title_fullStr A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo
title_full_unstemmed A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo
title_short A Novel Association Between Loop Diuretic Therapy and Repigmentation in Two Patients With Vitiligo
title_sort novel association between loop diuretic therapy and repigmentation in two patients with vitiligo
topic Dermatology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484005/
https://www.ncbi.nlm.nih.gov/pubmed/36159953
http://dx.doi.org/10.7759/cureus.16836
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