Percutaneous coronary intervention in insulin‐treated diabetic patients: A meta‐analysis

BACKGROUND: This meta‐analysis of randomized controlled trials (RCTs) compared long‐term adverse clinical outcomes of percutaneous coronary intervention (PCI) in insulin‐treated diabetes mellitus (ITDM) and non‐ITDM patients. METHODS: This is a meta‐analysis study. The PubMed and Embase databases were searched for articles on long‐term adverse clinical outcomes of PCI in ITDM and non‐ITDM patients. The risk ratios (RR) and 95% confidence intervals (CI) were calculated. RESULTS: A total of 11 related RCTs involving 8853 DM patients were included. Compared with non‐ITDM patients, ITDM patients had significantly higher all‐cause mortality (ACM) (RR = 1.52, 95% CI: 1.25–1.85, p (heterogeneity) = .689, I (2) = 0%), major adverse cardiac and cerebrovascular events (MACCE) (RR = 1.35, 95% CI: 1.18–1.55, p (heterogeneity) = .57, I (2) = 0%), myocardial infarction (MI) (RR = 1.41, 95% CI: 1.16–1.72, p (heterogeneity) = .962, I (2) = 0%), and stent thrombosis (ST) (RR = 1.75, 95% CI: 1.23–2.48, p (heterogeneity) = .159, I (2) = 32.4%). No significant difference was found in the target lesion revascularization (TLR) and target vessel revascularization (TVR) between the ITDM and non‐ITDM groups. CONCLUSIONS: The results showed that ITDM patients had significantly higher ACM, MACCE, MI, and ST, compared with non‐ITDM patients.