TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome

Corticotroph macroadenomas are rare but difficult to manage intracranial neoplasms. Mutations in the two Cushing’s disease mutational hotspots USP8 and USP48 are less frequent in corticotroph macroadenomas and invasive tumors. There is evidence that TP53 mutations are not as rare as previously thoug...

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Detalles Bibliográficos
Autores principales: Perez-Rivas, Luis Gustavo, Simon, Julia, Albani, Adriana, Tang, Sicheng, Roeber, Sigrun, Assié, Guillaume, Deutschbein, Timo, Fassnacht, Martin, Gadelha, Monica R., Hermus, Ad R., Stalla, Günter K., Tichomirowa, Maria A., Rotermund, Roman, Flitsch, Jörg, Buchfelder, Michael, Nasi-Kordhishti, Isabella, Honegger, Jürgen, Thorsteinsdottir, Jun, Saeger, Wolfgang, Herms, Jochen, Reincke, Martin, Theodoropoulou, Marily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484083/
https://www.ncbi.nlm.nih.gov/pubmed/36123588
http://dx.doi.org/10.1186/s40478-022-01437-1

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