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Striatal Induction and Spread of the Huntington’s Disease Protein: A Novel Rhes Route
The CAG/CAA expansion encoding polyQ huntingtin (mutant huntingtin [mHTT]) causes Huntington’s disease (HD), which is characterized by atrophy and loss of striatal medium spiny neurons (MSNs), which are preceded by neuropathological alterations in the cortex. Previous studies have shown that mHTT ca...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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IOS Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484121/ https://www.ncbi.nlm.nih.gov/pubmed/35871361 http://dx.doi.org/10.3233/JHD-220548 |