Decoding human-macaque interspecies differences in Fc-effector functions: The structural basis for CD16-dependent effector function in Rhesus macaques

Fc mediated effector functions of antibodies play important roles in immunotherapies and vaccine efficacy but assessing those functions in animal models can be challenging due to species differences. Rhesus macaques, Macaca mulatta (Mm) share approximately 93% sequence identity with humans but displ...

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Detalles Bibliográficos
Autores principales: Tolbert, William D., Gohain, Neelakshi, Kremer, Paul G., Hederman, Andrew P., Nguyen, Dung N., Van, Verna, Sherburn, Rebekah, Lewis, George K., Finzi, Andrés, Pollara, Justin, Ackerman, Margaret E., Barb, Adam W., Pazgier, Marzena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484259/
https://www.ncbi.nlm.nih.gov/pubmed/36131913
http://dx.doi.org/10.3389/fimmu.2022.960411

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