Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia

The central nervous system is often a site of spread for patients with acute lymphoblastic leukemia (ALL). ALL is often treated with ongoing intrathecal chemotherapy with the most common regimens including methotrexate and/or cytarabine. Uncommonly, intrathecal methotrexate has been associated with...

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Autores principales: Tang, Wesley, Tan, Jennie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484505/
https://www.ncbi.nlm.nih.gov/pubmed/36131864
http://dx.doi.org/10.4103/ijabmr.ijabmr_729_21
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author Tang, Wesley
Tan, Jennie
author_facet Tang, Wesley
Tan, Jennie
author_sort Tang, Wesley
collection PubMed
description The central nervous system is often a site of spread for patients with acute lymphoblastic leukemia (ALL). ALL is often treated with ongoing intrathecal chemotherapy with the most common regimens including methotrexate and/or cytarabine. Uncommonly, intrathecal methotrexate has been associated with stroke-like symptoms. To the author’s knowledge, we present the first reported case of a patient who developed symptoms more akin to bacterial meningitis than stroke-like symptoms as a consequence of intrathecal methotrexate chemotherapy.
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spelling pubmed-94845052022-09-20 Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia Tang, Wesley Tan, Jennie Int J Appl Basic Med Res Case Report The central nervous system is often a site of spread for patients with acute lymphoblastic leukemia (ALL). ALL is often treated with ongoing intrathecal chemotherapy with the most common regimens including methotrexate and/or cytarabine. Uncommonly, intrathecal methotrexate has been associated with stroke-like symptoms. To the author’s knowledge, we present the first reported case of a patient who developed symptoms more akin to bacterial meningitis than stroke-like symptoms as a consequence of intrathecal methotrexate chemotherapy. Wolters Kluwer - Medknow 2022 2022-07-26 /pmc/articles/PMC9484505/ /pubmed/36131864 http://dx.doi.org/10.4103/ijabmr.ijabmr_729_21 Text en Copyright: © 2022 International Journal of Applied and Basic Medical Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Tang, Wesley
Tan, Jennie
Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia
title Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia
title_full Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia
title_fullStr Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia
title_full_unstemmed Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia
title_short Intrathecal Methotrexate-Induced Aseptic Meningitis in a Patient with Acute Lymphoblastic Leukemia
title_sort intrathecal methotrexate-induced aseptic meningitis in a patient with acute lymphoblastic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484505/
https://www.ncbi.nlm.nih.gov/pubmed/36131864
http://dx.doi.org/10.4103/ijabmr.ijabmr_729_21
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AT tanjennie intrathecalmethotrexateinducedasepticmeningitisinapatientwithacutelymphoblasticleukemia

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