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Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is currently the second leading cause of cancer-related deaths worldwide, with high morbidity and mortality. The clinical diagnosis of HCC mainly depends on imaging technology, such as ultrasound and computed tomography, and serum biomarkers, such as alpha-fetoprotein...

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Detalles Bibliográficos
Autor principal: Chen, Tingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484560/
https://www.ncbi.nlm.nih.gov/pubmed/36132427
http://dx.doi.org/10.2147/JHC.S380237
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author Chen, Tingsong
author_facet Chen, Tingsong
author_sort Chen, Tingsong
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description Hepatocellular carcinoma (HCC) is currently the second leading cause of cancer-related deaths worldwide, with high morbidity and mortality. The clinical diagnosis of HCC mainly depends on imaging technology, such as ultrasound and computed tomography, and serum biomarkers, such as alpha-fetoprotein (AFP). However, HCC is still hard to diagnose at an early stage due to the low sensitivity of the above mentioned traditional methods. Typically, HCC is diagnosed at an advanced stage when limited treatment options are available. It is urgent to identify effective biomarkers for the early diagnosis of HCC. Increasing evidence uncovered ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), could be used in HCC diagnosis. The aim of this review is to summarize our understanding of circulating miRNAs, lncRNAs and circRNAs as fluid-based non-invasive biomarkers, and aiming at providing new insights into the diagnosis of HCC.
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spelling pubmed-94845602022-09-20 Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma Chen, Tingsong J Hepatocell Carcinoma Review Hepatocellular carcinoma (HCC) is currently the second leading cause of cancer-related deaths worldwide, with high morbidity and mortality. The clinical diagnosis of HCC mainly depends on imaging technology, such as ultrasound and computed tomography, and serum biomarkers, such as alpha-fetoprotein (AFP). However, HCC is still hard to diagnose at an early stage due to the low sensitivity of the above mentioned traditional methods. Typically, HCC is diagnosed at an advanced stage when limited treatment options are available. It is urgent to identify effective biomarkers for the early diagnosis of HCC. Increasing evidence uncovered ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), could be used in HCC diagnosis. The aim of this review is to summarize our understanding of circulating miRNAs, lncRNAs and circRNAs as fluid-based non-invasive biomarkers, and aiming at providing new insights into the diagnosis of HCC. Dove 2022-09-15 /pmc/articles/PMC9484560/ /pubmed/36132427 http://dx.doi.org/10.2147/JHC.S380237 Text en © 2022 Chen. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Chen, Tingsong
Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma
title Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma
title_full Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma
title_fullStr Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma
title_full_unstemmed Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma
title_short Circulating Non-Coding RNAs as Potential Diagnostic Biomarkers in Hepatocellular Carcinoma
title_sort circulating non-coding rnas as potential diagnostic biomarkers in hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484560/
https://www.ncbi.nlm.nih.gov/pubmed/36132427
http://dx.doi.org/10.2147/JHC.S380237
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