Cargando…
Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds
Antibiotic-resistant Escherichia coli infection of poultry causes significant economic losses. Extended spectrum β lactamases (ESBL) producing E. coli was inoculated in a broiler, Rhode Island Red and Haringhata Black birds orally at 56×10(8) c.f.u. mL(-1) for induction of diarrhoea. Pharmacokinetic...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Association of Physical Chemists
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484700/ https://www.ncbi.nlm.nih.gov/pubmed/36131891 http://dx.doi.org/10.5599/admet.1170 |
_version_ | 1784791930689814528 |
---|---|
author | Mithin, U.C. Buragohain, Rinku Das, Pradip K Mandal, Tapan K Hansda, Rabindra N Joardar, Siddhartha N Samanta, Indranil Sar, Tapas K |
author_facet | Mithin, U.C. Buragohain, Rinku Das, Pradip K Mandal, Tapan K Hansda, Rabindra N Joardar, Siddhartha N Samanta, Indranil Sar, Tapas K |
author_sort | Mithin, U.C. |
collection | PubMed |
description | Antibiotic-resistant Escherichia coli infection of poultry causes significant economic losses. Extended spectrum β lactamases (ESBL) producing E. coli was inoculated in a broiler, Rhode Island Red and Haringhata Black birds orally at 56×10(8) c.f.u. mL(-1) for induction of diarrhoea. Pharmacokinetics of ceftriaxone-tazobactam combination (8:1) was studied following a single intramuscular injection at 28.125 mg kg(-1) and the combination was administered twice daily to treat such infection. Plasma concentration of both ceftriaxone persisted up to 8 h in experimental birds and maintained an approximate ratio of 8:1 with tazobactam for a period of 2 h, 0.25 h and 0.75 h, respectively in a broiler, Rhode Island Red and Haringhata Black birds. The K(el) was significantly lower in all experimental birds compared to healthy birds. Efficacy study was conducted in diarrhoeic birds by administration of ceftriaxone-tazobactam combination at 28.125 mg kg(-1) body weight twice daily intramuscularly for three days which caused an increase in specific antibody titre in the broiler on 5(th) day and in Rhode Island Red birds 10(th) day. However, Haringhata black birds were inherently showed more resistance towards the infection. The combination of ceftriaxone and tazobactam in the ratio of 8:1 can be an effective treatment to combat ESBL producing E. coli infections. |
format | Online Article Text |
id | pubmed-9484700 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | International Association of Physical Chemists |
record_format | MEDLINE/PubMed |
spelling | pubmed-94847002022-09-20 Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds Mithin, U.C. Buragohain, Rinku Das, Pradip K Mandal, Tapan K Hansda, Rabindra N Joardar, Siddhartha N Samanta, Indranil Sar, Tapas K ADMET DMPK Original Scientific Paper Antibiotic-resistant Escherichia coli infection of poultry causes significant economic losses. Extended spectrum β lactamases (ESBL) producing E. coli was inoculated in a broiler, Rhode Island Red and Haringhata Black birds orally at 56×10(8) c.f.u. mL(-1) for induction of diarrhoea. Pharmacokinetics of ceftriaxone-tazobactam combination (8:1) was studied following a single intramuscular injection at 28.125 mg kg(-1) and the combination was administered twice daily to treat such infection. Plasma concentration of both ceftriaxone persisted up to 8 h in experimental birds and maintained an approximate ratio of 8:1 with tazobactam for a period of 2 h, 0.25 h and 0.75 h, respectively in a broiler, Rhode Island Red and Haringhata Black birds. The K(el) was significantly lower in all experimental birds compared to healthy birds. Efficacy study was conducted in diarrhoeic birds by administration of ceftriaxone-tazobactam combination at 28.125 mg kg(-1) body weight twice daily intramuscularly for three days which caused an increase in specific antibody titre in the broiler on 5(th) day and in Rhode Island Red birds 10(th) day. However, Haringhata black birds were inherently showed more resistance towards the infection. The combination of ceftriaxone and tazobactam in the ratio of 8:1 can be an effective treatment to combat ESBL producing E. coli infections. International Association of Physical Chemists 2022-09-13 /pmc/articles/PMC9484700/ /pubmed/36131891 http://dx.doi.org/10.5599/admet.1170 Text en Copyright © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ). |
spellingShingle | Original Scientific Paper Mithin, U.C. Buragohain, Rinku Das, Pradip K Mandal, Tapan K Hansda, Rabindra N Joardar, Siddhartha N Samanta, Indranil Sar, Tapas K Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds |
title | Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds |
title_full | Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds |
title_fullStr | Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds |
title_full_unstemmed | Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds |
title_short | Pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and Escherichia coli induced diarrhoeic birds |
title_sort | pharmacokinetics of ceftriaxone-tazobactam (8:1) combination in healthy and escherichia coli induced diarrhoeic birds |
topic | Original Scientific Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484700/ https://www.ncbi.nlm.nih.gov/pubmed/36131891 http://dx.doi.org/10.5599/admet.1170 |
work_keys_str_mv | AT mithinuc pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT buragohainrinku pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT daspradipk pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT mandaltapank pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT hansdarabindran pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT joardarsiddharthan pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT samantaindranil pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds AT sartapask pharmacokineticsofceftriaxonetazobactam81combinationinhealthyandescherichiacoliinduceddiarrhoeicbirds |