Cargando…
The allosteric mechanism leading to an open-groove lipid conductive state of the TMEM16F scramblase
TMEM16F is a Ca(2+)-activated phospholipid scramblase in the TMEM16 family of membrane proteins. Unlike other TMEM16s exhibiting a membrane-exposed hydrophilic groove that serves as a translocation pathway for lipids, the experimentally determined structures of TMEM16F shows the groove in a closed c...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484709/ https://www.ncbi.nlm.nih.gov/pubmed/36123525 http://dx.doi.org/10.1038/s42003-022-03930-8 |