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Breast Carcinoma Receptor Expression in a Caribbean Population
Trinidad and Tobago are islands in the Southern Caribbean with a unique mix of races within the population consisting of East Indian (EI) (37.6%), Afro-Caribbean (AC) (36.3%), mixed (24.2%), and Caucasian, Chinese, Lebanese, Syrian, Amerindian, and Spanish groups accounting for 1.9%. It makes it sui...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Thieme Medical Publishers, Inc.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484866/ https://www.ncbi.nlm.nih.gov/pubmed/36131945 http://dx.doi.org/10.1055/s-0042-1756632 |
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author | Ramdass, Michael J. Gonzales, Joshua Maharaj, Dale Simeon, Donald Barrow, Shaheeba |
author_facet | Ramdass, Michael J. Gonzales, Joshua Maharaj, Dale Simeon, Donald Barrow, Shaheeba |
author_sort | Ramdass, Michael J. |
collection | PubMed |
description | Trinidad and Tobago are islands in the Southern Caribbean with a unique mix of races within the population consisting of East Indian (EI) (37.6%), Afro-Caribbean (AC) (36.3%), mixed (24.2%), and Caucasian, Chinese, Lebanese, Syrian, Amerindian, and Spanish groups accounting for 1.9%. It makes it suitable for a comparison of breast carcinoma receptor expression within a fixed environment. This study included 257 women with an age range of 28 to 93 years (mean = 57.2, standard deviation = 15.0), peak age group of 51 to 60 consisting of 105 EI, 119 AC, and 33 mixed descent. Invasive ductal carcinoma accounted for 88%, invasive lobular 9.7%, and ductal carcinoma in situ 2.3%. The triple-negative rates were 24.8, 33.6, and 30.3% for EI, AC, and mixed races, respectively, with the Pearson's chi-square test revealing statistical significance for the AC versus EI ( p < 0.001); AC versus mixed ( p < 0.001); and EI versus mixed ( p = 0.014) groups. The overall estrogen (ER), progesterone (PR), and human epidermal growth receptor (HER) expression negative rates were 52, 64, and 79%, respectively. Chi-square test of the following combinations: ER +/PR +/HER + ; ER +/PR +/HER − ; ER −/PR −/HER + ; ER +/PR −/HER + ; ER +/PR −/HER − ; ER −/PR +/HER + ; ER −/PR +/HER− revealed no statistical differences ( p = 0.689). |
format | Online Article Text |
id | pubmed-9484866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Thieme Medical Publishers, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-94848662022-09-20 Breast Carcinoma Receptor Expression in a Caribbean Population Ramdass, Michael J. Gonzales, Joshua Maharaj, Dale Simeon, Donald Barrow, Shaheeba Surg J (N Y) Trinidad and Tobago are islands in the Southern Caribbean with a unique mix of races within the population consisting of East Indian (EI) (37.6%), Afro-Caribbean (AC) (36.3%), mixed (24.2%), and Caucasian, Chinese, Lebanese, Syrian, Amerindian, and Spanish groups accounting for 1.9%. It makes it suitable for a comparison of breast carcinoma receptor expression within a fixed environment. This study included 257 women with an age range of 28 to 93 years (mean = 57.2, standard deviation = 15.0), peak age group of 51 to 60 consisting of 105 EI, 119 AC, and 33 mixed descent. Invasive ductal carcinoma accounted for 88%, invasive lobular 9.7%, and ductal carcinoma in situ 2.3%. The triple-negative rates were 24.8, 33.6, and 30.3% for EI, AC, and mixed races, respectively, with the Pearson's chi-square test revealing statistical significance for the AC versus EI ( p < 0.001); AC versus mixed ( p < 0.001); and EI versus mixed ( p = 0.014) groups. The overall estrogen (ER), progesterone (PR), and human epidermal growth receptor (HER) expression negative rates were 52, 64, and 79%, respectively. Chi-square test of the following combinations: ER +/PR +/HER + ; ER +/PR +/HER − ; ER −/PR −/HER + ; ER +/PR −/HER + ; ER +/PR −/HER − ; ER −/PR +/HER + ; ER −/PR +/HER− revealed no statistical differences ( p = 0.689). Thieme Medical Publishers, Inc. 2022-09-19 /pmc/articles/PMC9484866/ /pubmed/36131945 http://dx.doi.org/10.1055/s-0042-1756632 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. ( https://creativecommons.org/licenses/by/4.0/ ) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Ramdass, Michael J. Gonzales, Joshua Maharaj, Dale Simeon, Donald Barrow, Shaheeba Breast Carcinoma Receptor Expression in a Caribbean Population |
title | Breast Carcinoma Receptor Expression in a Caribbean Population |
title_full | Breast Carcinoma Receptor Expression in a Caribbean Population |
title_fullStr | Breast Carcinoma Receptor Expression in a Caribbean Population |
title_full_unstemmed | Breast Carcinoma Receptor Expression in a Caribbean Population |
title_short | Breast Carcinoma Receptor Expression in a Caribbean Population |
title_sort | breast carcinoma receptor expression in a caribbean population |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484866/ https://www.ncbi.nlm.nih.gov/pubmed/36131945 http://dx.doi.org/10.1055/s-0042-1756632 |
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