Cargando…

Electroacupuncture Improves Intestinal Motility through Exosomal miR-34c-5p Targeting SCF/c-Kit Signaling Pathway in Slow Transit Constipation Model Rats

BACKGROUND: The pathogenesis of slow transit constipation (STC) is associated with exosomal miR-34c-5p. Electroacupuncture (EA) improves gastrointestinal motility in gastrointestinal disorders, especially STC. Our study aimed to explore the mechanism by which EA improves intestinal motility by modul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuang, Hongjun, Zhang, Chengshun, Zhang, Wei, Cai, Huzhi, Yang, Layuan, Yuan, Nan, Yuan, Yangyang, Yang, Yutao, Zuo, Chuanyi, Zhong, Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484875/ https://www.ncbi.nlm.nih.gov/pubmed/36133788 http://dx.doi.org/10.1155/2022/8043841

Ejemplares similares

Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor
por: Zhang, Dengyang, et al.
Publicado: (2022)

Naringenin induces laxative effects by upregulating the expression levels of c-Kit and SCF, as well as those of aquaporin 3 in mice with loperamide-induced constipation
por: Yin, Jianqiao, et al.
Publicado: (2018)

c-KIT and c-KIT ligand (SCF) in synovial sarcoma (SS): an mRNA expression analysis in 23 cases
por: Tamborini, E, et al.
Publicado: (2001)

Molecular Characterization of PDGFR-α/PDGF-A and c-KIT/SCF in Gliosarcomas
por: Reis, Rui M., et al.
Publicado: (2005)

Lnk-dependent axis of SCF–cKit signal for osteogenesis in bone fracture healing
por: Matsumoto, Tomoyuki, et al.
Publicado: (2010)

In cancer cell lines inhibition of SCF/c-Kit pathway leads to radiosensitization only when SCF is strongly over-expressed
por: Eberle, Fabian, et al.
Publicado: (2017)

Parkinson's disease constipation effect of electroacupuncture at ST25 through colonic motility and enteric neuropathology
por: Song, Li-zhe-xiong, et al.
Publicado: (2023)

Electroacupuncture at ST36 Protects ICC Networks via mSCF/Kit-ETV1 Signaling in the Stomach of Diabetic Mice
por: Tian, Lugao, et al.
Publicado: (2017)

Glyceollins, a novel class of soybean phytoalexins, inhibit SCF-induced melanogenesis through attenuation of SCF/c-kit downstream signaling pathways
por: Shin, Sun-Hye, et al.
Publicado: (2013)

Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling
por: Roy, Lopamudra Das, et al.
Publicado: (2013)

GM-CSF Inhibits c-Kit and SCF Expression by Bone Marrow-Derived Dendritic Cells
por: Barroeta Seijas, Amairelys Belen, et al.
Publicado: (2017)

Autocrine/Paracrine Loop Between SCF(+)/c-Kit(+) Mast Cells Promotes Cutaneous Melanoma Progression
por: Annese, Tiziana, et al.
Publicado: (2022)

SCF/c-KIT Signaling Increased Mucin2 Production by Maintaining Atoh1 Expression in Mucinous Colorectal Adenocarcinoma
por: Shen, Ping, et al.
Publicado: (2018)

SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma
por: Wang, Yaxi, et al.
Publicado: (2017)

Differential regulation of gene expression in mouse spermatogonial cells after blocking c-kit-SCF interaction with RNAi
por: Sikarwar, Arun P, et al.
Publicado: (2008)

Electroacupuncture Regulates Apoptosis/Proliferation of Intramuscular Interstitial Cells of Cajal and Restores Colonic Motility in Diabetic Constipation Rats
por: Xu, Juanjuan, et al.
Publicado: (2013)

A role for stem cell factor (SCF): c-kit interaction(s) in the intestinal tract response to Salmonella typhimurium infection
Publicado: (1996)

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases
por: Drube, Sebastian, et al.
Publicado: (2015)

SCF/c-Kit-activated signaling and angiogenesis require Gαi1 and Gαi3
por: Shan, Hua-jian, et al.
Publicado: (2023)

Yangyin Runchang Decoction Improves Intestinal Motility in Mice with Atropine/Diphenoxylate-Induced Slow-Transit Constipation
por: Jiang, Feng, et al.
Publicado: (2017)

The Effectiveness of Electroacupuncture for Functional Constipation: A Randomized, Controlled, Clinical Trial
por: Da, Nili, et al.
Publicado: (2015)

Microbial Profiles of Patients With Antipsychotic-Related Constipation Treated With Electroacupuncture
por: Zheng, Yuanjia, et al.
Publicado: (2021)

Colonic motor response to wakening is blunted in slow transit constipation as detected by wireless motility capsule
por: Surjanhata, Brian, et al.
Publicado: (2018)

Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility
por: Ge, Xiaolong, et al.
Publicado: (2017)

Curcumin improves expression of SCF/c-kit through attenuating oxidative stress and NF-κB activation in gastric tissues of diabetic gastroparesis rats
por: Jin, Qi-Hui, et al.
Publicado: (2013)

A Novel Slug-containing Negative Feedback Loop regulates SCF/c-Kit-Mediated Hematopoietic Stem Cell Self-renewal
por: Zhang, Zhonghui, et al.
Publicado: (2016)

Novel discovery of schisandrin A regulating the interplay of autophagy and apoptosis in oligoasthenospermia by targeting SCF/c-kit and TRPV1 via biosensors
por: Ma, Lijuan, et al.
Publicado: (2023)

SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions
por: Chen, Lei L., et al.
Publicado: (2017)

Tivozanib mediated inhibition of c-Kit/SCF signaling on Tregs and MDSCs and reversal of tumor induced immune suppression correlates with survival of HCC patients
por: Kalathil, Suresh Gopi, et al.
Publicado: (2020)

Effects of temporary sacral nerve stimulation on gastrointestinal motility and function in patients with chronic refractory slow-transit constipation
por: Altomare, D. F., et al.
Publicado: (2020)

Electroacupuncture at ST36 Increases Bone Marrow-Derived Interstitial Cells of Cajal via the SDF-1/CXCR4 and mSCF/Kit-ETV1 Pathways in the Stomach of Diabetic Mice
por: Zhao, Jiao, et al.
Publicado: (2018)

The effect and mechanism of electroacupuncture at LI11 and ST37 on constipation in a rat model
por: Zhu, Xianwei, et al.
Publicado: (2016)

Electroacupuncture for Functional Constipation: A Multicenter, Randomized, Control Trial
por: Wu, Xiao, et al.
Publicado: (2017)

Co expression of SCF and KIT in gastrointestinal stromal tumours (GISTs) suggests an autocrine/paracrine mechanism
por: Théou-Anton, N, et al.
Publicado: (2006)

Persistent distention of colon damages interstitial cells of Cajal through Ca(2+)‐ERK‐AP‐1‐miR‐34c‐SCF deregulation
por: Yang, Shu, et al.
Publicado: (2017)

Electroacupuncture at LI11 promotes jejunal motility via the parasympathetic pathway
por: Hu, Xuanming, et al.
Publicado: (2017)

Total Glucosides of Paeony Promote Intestinal Motility in Slow Transit Constipation Rats through Amelioration of Interstitial Cells of Cajal
por: Zhu, Feiye, et al.
Publicado: (2016)

Colonic electrical stimulation promotes colonic motility through regeneration of myenteric plexus neurons in slow transit constipation beagles
por: Wang, Yongbin, et al.
Publicado: (2019)

Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation
por: Yang, Shu, et al.
Publicado: (2016)

Effect of Electroacupuncture with Different Current Intensities on the Serum Metabolomics of Functional Constipation
por: Wu, Xiao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_8mom7c1svab7keoto7l132oi6a