Cargando…
Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). METHODS: A single-cen...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/ https://www.ncbi.nlm.nih.gov/pubmed/36132538 http://dx.doi.org/10.1155/2022/7418955 |
_version_ | 1784791992207671296 |
---|---|
author | Kahindo, Charles Kangitsi Mukuku, Olivier Mokoli, Vieux Momeme Sumaili, Ernest Kiswaya Wembonyama, Stanis Okitotsho Tsongo, Zacharie Kibendelwa |
author_facet | Kahindo, Charles Kangitsi Mukuku, Olivier Mokoli, Vieux Momeme Sumaili, Ernest Kiswaya Wembonyama, Stanis Okitotsho Tsongo, Zacharie Kibendelwa |
author_sort | Kahindo, Charles Kangitsi |
collection | PubMed |
description | INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). METHODS: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan–Meier curve. Predictors of mortality were evaluated using Cox regression. RESULTS: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18–90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98–63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10–12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48–20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08–43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26–30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07–10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51–36.89; p < 0.0001). CONCLUSION: Initiation of hemodialysis with AKI has improved survival in patients with different complications. |
format | Online Article Text |
id | pubmed-9484972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94849722022-09-20 Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis Kahindo, Charles Kangitsi Mukuku, Olivier Mokoli, Vieux Momeme Sumaili, Ernest Kiswaya Wembonyama, Stanis Okitotsho Tsongo, Zacharie Kibendelwa Int J Nephrol Research Article INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). METHODS: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan–Meier curve. Predictors of mortality were evaluated using Cox regression. RESULTS: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18–90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98–63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10–12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48–20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08–43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26–30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07–10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51–36.89; p < 0.0001). CONCLUSION: Initiation of hemodialysis with AKI has improved survival in patients with different complications. Hindawi 2022-09-12 /pmc/articles/PMC9484972/ /pubmed/36132538 http://dx.doi.org/10.1155/2022/7418955 Text en Copyright © 2022 Charles Kangitsi Kahindo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kahindo, Charles Kangitsi Mukuku, Olivier Mokoli, Vieux Momeme Sumaili, Ernest Kiswaya Wembonyama, Stanis Okitotsho Tsongo, Zacharie Kibendelwa Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis |
title | Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis |
title_full | Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis |
title_fullStr | Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis |
title_full_unstemmed | Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis |
title_short | Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis |
title_sort | predictors of mortality in adults with acute kidney injury requiring dialysis: a cohort analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/ https://www.ncbi.nlm.nih.gov/pubmed/36132538 http://dx.doi.org/10.1155/2022/7418955 |
work_keys_str_mv | AT kahindocharleskangitsi predictorsofmortalityinadultswithacutekidneyinjuryrequiringdialysisacohortanalysis AT mukukuolivier predictorsofmortalityinadultswithacutekidneyinjuryrequiringdialysisacohortanalysis AT mokolivieuxmomeme predictorsofmortalityinadultswithacutekidneyinjuryrequiringdialysisacohortanalysis AT sumailiernestkiswaya predictorsofmortalityinadultswithacutekidneyinjuryrequiringdialysisacohortanalysis AT wembonyamastanisokitotsho predictorsofmortalityinadultswithacutekidneyinjuryrequiringdialysisacohortanalysis AT tsongozachariekibendelwa predictorsofmortalityinadultswithacutekidneyinjuryrequiringdialysisacohortanalysis |