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Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis

INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). METHODS: A single-cen...

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Autores principales: Kahindo, Charles Kangitsi, Mukuku, Olivier, Mokoli, Vieux Momeme, Sumaili, Ernest Kiswaya, Wembonyama, Stanis Okitotsho, Tsongo, Zacharie Kibendelwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/
https://www.ncbi.nlm.nih.gov/pubmed/36132538
http://dx.doi.org/10.1155/2022/7418955
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author Kahindo, Charles Kangitsi
Mukuku, Olivier
Mokoli, Vieux Momeme
Sumaili, Ernest Kiswaya
Wembonyama, Stanis Okitotsho
Tsongo, Zacharie Kibendelwa
author_facet Kahindo, Charles Kangitsi
Mukuku, Olivier
Mokoli, Vieux Momeme
Sumaili, Ernest Kiswaya
Wembonyama, Stanis Okitotsho
Tsongo, Zacharie Kibendelwa
author_sort Kahindo, Charles Kangitsi
collection PubMed
description INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). METHODS: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan–Meier curve. Predictors of mortality were evaluated using Cox regression. RESULTS: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18–90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98–63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10–12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48–20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08–43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26–30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07–10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51–36.89; p < 0.0001). CONCLUSION: Initiation of hemodialysis with AKI has improved survival in patients with different complications.
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spelling pubmed-94849722022-09-20 Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis Kahindo, Charles Kangitsi Mukuku, Olivier Mokoli, Vieux Momeme Sumaili, Ernest Kiswaya Wembonyama, Stanis Okitotsho Tsongo, Zacharie Kibendelwa Int J Nephrol Research Article INTRODUCTION: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)). METHODS: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan–Meier curve. Predictors of mortality were evaluated using Cox regression. RESULTS: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18–90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98–63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10–12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48–20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08–43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26–30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07–10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51–36.89; p < 0.0001). CONCLUSION: Initiation of hemodialysis with AKI has improved survival in patients with different complications. Hindawi 2022-09-12 /pmc/articles/PMC9484972/ /pubmed/36132538 http://dx.doi.org/10.1155/2022/7418955 Text en Copyright © 2022 Charles Kangitsi Kahindo et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kahindo, Charles Kangitsi
Mukuku, Olivier
Mokoli, Vieux Momeme
Sumaili, Ernest Kiswaya
Wembonyama, Stanis Okitotsho
Tsongo, Zacharie Kibendelwa
Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
title Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
title_full Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
title_fullStr Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
title_full_unstemmed Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
title_short Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis
title_sort predictors of mortality in adults with acute kidney injury requiring dialysis: a cohort analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/
https://www.ncbi.nlm.nih.gov/pubmed/36132538
http://dx.doi.org/10.1155/2022/7418955
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