Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm

Silencing of endogenous retroviruses (ERVs) is largely mediated by repressive chromatin modifications H3K9me3 and DNA methylation. On ERVs, these modifications are mainly deposited by the histone methyltransferase Setdb1 and by the maintenance DNA methyltransferase Dnmt1. Knock-out of either Setdb1...

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Detalles Bibliográficos
Autores principales: Wang, Zeyang, Fan, Rui, Russo, Angela, Cernilogar, Filippo M., Nuber, Alexander, Schirge, Silvia, Shcherbakova, Irina, Dzhilyanova, Iva, Ugur, Enes, Anton, Tobias, Richter, Lisa, Leonhardt, Heinrich, Lickert, Heiko, Schotta, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485127/
https://www.ncbi.nlm.nih.gov/pubmed/36123357
http://dx.doi.org/10.1038/s41467-022-32978-7

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