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The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry

We investigated the prognostic effects of hyperuricemia and high or low body mass index (BMI) in peripheral artery disease (PAD) after endovascular therapy (EVT). Between July 2015–2016, 357 consecutive patients with PAD who underwent EVT were enrolled. Patients were divided into 2 groups: BMI <...

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Autores principales: Nagae, Ayumu, Ebisawa, Soichiro, Saigusa, Tatsuya, Nishikawa, Ken, Fujimori, Koki, Yui, Hisanori, Maruyama, Shusaku, Nakamura, Chie, Kashiwagi, Daisuke, Kobayashi, Hideki, Sakai, Takahiro, Senda, Keisuke, Kato, Tamon, Miura, Takashi, Okada, Ayako, Motoki, Hirohiko, Kuwahara, Koichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485156/
https://www.ncbi.nlm.nih.gov/pubmed/35077237
http://dx.doi.org/10.1177/00033197211072344
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author Nagae, Ayumu
Ebisawa, Soichiro
Saigusa, Tatsuya
Nishikawa, Ken
Fujimori, Koki
Yui, Hisanori
Maruyama, Shusaku
Nakamura, Chie
Kashiwagi, Daisuke
Kobayashi, Hideki
Sakai, Takahiro
Senda, Keisuke
Kato, Tamon
Miura, Takashi
Okada, Ayako
Motoki, Hirohiko
Kuwahara, Koichiro
author_facet Nagae, Ayumu
Ebisawa, Soichiro
Saigusa, Tatsuya
Nishikawa, Ken
Fujimori, Koki
Yui, Hisanori
Maruyama, Shusaku
Nakamura, Chie
Kashiwagi, Daisuke
Kobayashi, Hideki
Sakai, Takahiro
Senda, Keisuke
Kato, Tamon
Miura, Takashi
Okada, Ayako
Motoki, Hirohiko
Kuwahara, Koichiro
author_sort Nagae, Ayumu
collection PubMed
description We investigated the prognostic effects of hyperuricemia and high or low body mass index (BMI) in peripheral artery disease (PAD) after endovascular therapy (EVT). Between July 2015–2016, 357 consecutive patients with PAD who underwent EVT were enrolled. Patients were divided into 2 groups: BMI < 25 kg/m(2) (low BMI) and ≥ 25 kg/m(2) (high BMI); they were also divided into 2 more groups based on the presence/absence of hyperuricemia. The primary and secondary endpoints were major adverse cardiovascular and limb events (MACLE), and all-cause death at 3 years post-EVT. Patients with hyperuricemia had significantly lower freedom from MACLE than patients without hyperuricemia at 3 years (57.0 vs 71.9%, p = .0068). The overall survival of patients with hyperuricemia was significantly lower than that of patients without hyperuricemia (63.9 vs 81.7%, p = .0012). Patients with hyperuricemia who had low BMI experienced significantly lower freedom from MACLE than those without hyperuricemia who had low BMI (48.2 vs 69.9%, p = .002). The overall survival of patients with hyperuricemia who had low BMI was significantly lower than that of patients without hyperuricemia who had low BMI (55.2 vs 77.1%, p = .003). Patients with hyperuricemia had significantly more MACLE and a lower survival at 3 years than patients without hyperuricemia, even if they had a low BMI.
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spelling pubmed-94851562022-09-21 The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry Nagae, Ayumu Ebisawa, Soichiro Saigusa, Tatsuya Nishikawa, Ken Fujimori, Koki Yui, Hisanori Maruyama, Shusaku Nakamura, Chie Kashiwagi, Daisuke Kobayashi, Hideki Sakai, Takahiro Senda, Keisuke Kato, Tamon Miura, Takashi Okada, Ayako Motoki, Hirohiko Kuwahara, Koichiro Angiology Peripheral Artery Disease We investigated the prognostic effects of hyperuricemia and high or low body mass index (BMI) in peripheral artery disease (PAD) after endovascular therapy (EVT). Between July 2015–2016, 357 consecutive patients with PAD who underwent EVT were enrolled. Patients were divided into 2 groups: BMI < 25 kg/m(2) (low BMI) and ≥ 25 kg/m(2) (high BMI); they were also divided into 2 more groups based on the presence/absence of hyperuricemia. The primary and secondary endpoints were major adverse cardiovascular and limb events (MACLE), and all-cause death at 3 years post-EVT. Patients with hyperuricemia had significantly lower freedom from MACLE than patients without hyperuricemia at 3 years (57.0 vs 71.9%, p = .0068). The overall survival of patients with hyperuricemia was significantly lower than that of patients without hyperuricemia (63.9 vs 81.7%, p = .0012). Patients with hyperuricemia who had low BMI experienced significantly lower freedom from MACLE than those without hyperuricemia who had low BMI (48.2 vs 69.9%, p = .002). The overall survival of patients with hyperuricemia who had low BMI was significantly lower than that of patients without hyperuricemia who had low BMI (55.2 vs 77.1%, p = .003). Patients with hyperuricemia had significantly more MACLE and a lower survival at 3 years than patients without hyperuricemia, even if they had a low BMI. SAGE Publications 2022-01-25 2022-09 /pmc/articles/PMC9485156/ /pubmed/35077237 http://dx.doi.org/10.1177/00033197211072344 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Peripheral Artery Disease
Nagae, Ayumu
Ebisawa, Soichiro
Saigusa, Tatsuya
Nishikawa, Ken
Fujimori, Koki
Yui, Hisanori
Maruyama, Shusaku
Nakamura, Chie
Kashiwagi, Daisuke
Kobayashi, Hideki
Sakai, Takahiro
Senda, Keisuke
Kato, Tamon
Miura, Takashi
Okada, Ayako
Motoki, Hirohiko
Kuwahara, Koichiro
The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
title The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
title_full The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
title_fullStr The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
title_full_unstemmed The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
title_short The Impact of Hyperuricemia on Patients With Low Body Mass Index After Endovascular Treatments: Data From the I-PAD Registry
title_sort impact of hyperuricemia on patients with low body mass index after endovascular treatments: data from the i-pad registry
topic Peripheral Artery Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485156/
https://www.ncbi.nlm.nih.gov/pubmed/35077237
http://dx.doi.org/10.1177/00033197211072344
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