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Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2
Atypical responses to sensory stimuli are considered as a core aspect and early life marker of autism spectrum disorders (ASD). Although recent findings performed in mouse ASD genetic models report sensory deficits, these were explored exclusively during juvenile or adult period. Whether sensory dys...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485246/ https://www.ncbi.nlm.nih.gov/pubmed/35396500 http://dx.doi.org/10.1038/s41386-022-01313-5 |
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author | Da Prato, Laura Caccialupi Zayan, Ugo Abdallah, Dina Point, Vanessa Schaller, Fabienne Pallesi-Pocachard, Emilie Montheil, Aurélie Canaan, Stéphane Gaiarsa, Jean-Luc Muscatelli, Françoise Matarazzo, Valéry |
author_facet | Da Prato, Laura Caccialupi Zayan, Ugo Abdallah, Dina Point, Vanessa Schaller, Fabienne Pallesi-Pocachard, Emilie Montheil, Aurélie Canaan, Stéphane Gaiarsa, Jean-Luc Muscatelli, Françoise Matarazzo, Valéry |
author_sort | Da Prato, Laura Caccialupi |
collection | PubMed |
description | Atypical responses to sensory stimuli are considered as a core aspect and early life marker of autism spectrum disorders (ASD). Although recent findings performed in mouse ASD genetic models report sensory deficits, these were explored exclusively during juvenile or adult period. Whether sensory dysfunctions might be present at the early life stage and rescued by therapeutic strategy are fairly uninvestigated. Here we found that under cool environment neonatal mice lacking the autism-associated gene Magel2 present pup calls hypo-reactivity and are retrieved with delay by their wild-type dam. This neonatal atypical sensory reactivity to cool stimuli was not associated with autonomic thermoregulatory alteration but with a deficit of the oxytocinergic system. Indeed, we show in control neonates that pharmacogenetic inactivation of hypothalamic oxytocin neurons mimicked atypical thermosensory reactivity found in Magel2 mutants. Furthermore, pharmacological intranasal administration of oxytocin to Magel2 neonates was able to rescue both the atypical thermosensory response and the maternal pup retrieval. This preclinical study establishes for the first-time early life impairments in thermosensory integration and suggest a therapeutic potential benefit of intranasal oxytocin treatment on neonatal atypical sensory reactivity for autism. |
format | Online Article Text |
id | pubmed-9485246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-94852462022-09-21 Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 Da Prato, Laura Caccialupi Zayan, Ugo Abdallah, Dina Point, Vanessa Schaller, Fabienne Pallesi-Pocachard, Emilie Montheil, Aurélie Canaan, Stéphane Gaiarsa, Jean-Luc Muscatelli, Françoise Matarazzo, Valéry Neuropsychopharmacology Article Atypical responses to sensory stimuli are considered as a core aspect and early life marker of autism spectrum disorders (ASD). Although recent findings performed in mouse ASD genetic models report sensory deficits, these were explored exclusively during juvenile or adult period. Whether sensory dysfunctions might be present at the early life stage and rescued by therapeutic strategy are fairly uninvestigated. Here we found that under cool environment neonatal mice lacking the autism-associated gene Magel2 present pup calls hypo-reactivity and are retrieved with delay by their wild-type dam. This neonatal atypical sensory reactivity to cool stimuli was not associated with autonomic thermoregulatory alteration but with a deficit of the oxytocinergic system. Indeed, we show in control neonates that pharmacogenetic inactivation of hypothalamic oxytocin neurons mimicked atypical thermosensory reactivity found in Magel2 mutants. Furthermore, pharmacological intranasal administration of oxytocin to Magel2 neonates was able to rescue both the atypical thermosensory response and the maternal pup retrieval. This preclinical study establishes for the first-time early life impairments in thermosensory integration and suggest a therapeutic potential benefit of intranasal oxytocin treatment on neonatal atypical sensory reactivity for autism. Springer International Publishing 2022-04-08 2022-10 /pmc/articles/PMC9485246/ /pubmed/35396500 http://dx.doi.org/10.1038/s41386-022-01313-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | Article Da Prato, Laura Caccialupi Zayan, Ugo Abdallah, Dina Point, Vanessa Schaller, Fabienne Pallesi-Pocachard, Emilie Montheil, Aurélie Canaan, Stéphane Gaiarsa, Jean-Luc Muscatelli, Françoise Matarazzo, Valéry Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 |
title | Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 |
title_full | Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 |
title_fullStr | Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 |
title_full_unstemmed | Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 |
title_short | Early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene Magel2 |
title_sort | early life oxytocin treatment improves thermo-sensory reactivity and maternal behavior in neonates lacking the autism-associated gene magel2 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485246/ https://www.ncbi.nlm.nih.gov/pubmed/35396500 http://dx.doi.org/10.1038/s41386-022-01313-5 |
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