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Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma

One of the most common primary bone malignant tumors is osteosarcoma (OS), possessing a high tendency of local invasion and distant metastasis. Although surgery combined with chemotherapy can extend the patients’ survival time, the prognosis for most patients with metastases or relapses is poor. Imm...

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Autores principales: Peng, Lijun, Fang, Huapan, Yang, Xiao, Zeng, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485470/
https://www.ncbi.nlm.nih.gov/pubmed/36147250
http://dx.doi.org/10.3389/fchem.2022.847621
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author Peng, Lijun
Fang, Huapan
Yang, Xiao
Zeng, Xi
author_facet Peng, Lijun
Fang, Huapan
Yang, Xiao
Zeng, Xi
author_sort Peng, Lijun
collection PubMed
description One of the most common primary bone malignant tumors is osteosarcoma (OS), possessing a high tendency of local invasion and distant metastasis. Although surgery combined with chemotherapy can extend the patients’ survival time, the prognosis for most patients with metastases or relapses is poor. Immunotherapy has been proved to be a promising treatment alternative for malignant tumors. Although there is a significant amount of animal- and cell-based evidence supporting the relationship between immune checkpoint inhibitors (anti-PD-1, anti-PD-L1, anti-CTLA-4) and cancers, no pan-cancer analysis is available. Simultaneously, immune checkpoint inhibitors have demonstrated satisfactory clinical results in some tumors; however, only a small fraction of patients with certain cancer types have been benefitted. Therefore, based on the TCGA dataset, we first explored the potential roles of immune checkpoints in 33 tumors. Programmed death receptor 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic T lymphocyte antigen 4 (CTLA-4) were not consistently expressed in the same direction in all tumors; however, the direction of expression change was the same in most immune cells. Although there is no well-established relationship between the expression of PD-1/PD-L1/CTLA-4 genes and the prognosis of patients with sarcomas, their interaction and extent of immune cell infiltration into sarcomas are probably the key determinants of therapeutic response. Our first pan-cancer study provides a relatively comprehensive understanding of immune checkpoint inhibitors in different sarcomas.
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spelling pubmed-94854702022-09-21 Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma Peng, Lijun Fang, Huapan Yang, Xiao Zeng, Xi Front Chem Chemistry One of the most common primary bone malignant tumors is osteosarcoma (OS), possessing a high tendency of local invasion and distant metastasis. Although surgery combined with chemotherapy can extend the patients’ survival time, the prognosis for most patients with metastases or relapses is poor. Immunotherapy has been proved to be a promising treatment alternative for malignant tumors. Although there is a significant amount of animal- and cell-based evidence supporting the relationship between immune checkpoint inhibitors (anti-PD-1, anti-PD-L1, anti-CTLA-4) and cancers, no pan-cancer analysis is available. Simultaneously, immune checkpoint inhibitors have demonstrated satisfactory clinical results in some tumors; however, only a small fraction of patients with certain cancer types have been benefitted. Therefore, based on the TCGA dataset, we first explored the potential roles of immune checkpoints in 33 tumors. Programmed death receptor 1 (PD-1), programmed cell death ligand 1 (PD-L1), and cytotoxic T lymphocyte antigen 4 (CTLA-4) were not consistently expressed in the same direction in all tumors; however, the direction of expression change was the same in most immune cells. Although there is no well-established relationship between the expression of PD-1/PD-L1/CTLA-4 genes and the prognosis of patients with sarcomas, their interaction and extent of immune cell infiltration into sarcomas are probably the key determinants of therapeutic response. Our first pan-cancer study provides a relatively comprehensive understanding of immune checkpoint inhibitors in different sarcomas. Frontiers Media S.A. 2022-09-06 /pmc/articles/PMC9485470/ /pubmed/36147250 http://dx.doi.org/10.3389/fchem.2022.847621 Text en Copyright © 2022 Peng, Fang, Yang and Zeng. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Peng, Lijun
Fang, Huapan
Yang, Xiao
Zeng, Xi
Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
title Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
title_full Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
title_fullStr Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
title_full_unstemmed Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
title_short Analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
title_sort analysis of combination therapy of immune checkpoint inhibitors in osteosarcoma
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485470/
https://www.ncbi.nlm.nih.gov/pubmed/36147250
http://dx.doi.org/10.3389/fchem.2022.847621
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