Identification of drivers of mycobacterial resistance to peptidoglycan synthesis inhibitors

Beta-lactams have been excluded from tuberculosis therapy due to the intrinsic resistance of Mycobacterium tuberculosis (Mtb) to this antibiotic class, usually attributed to a potent beta-lactamase, BlaC, and to an unusually complex cell wall. In this pathogen, the peptidoglycan is cross-linked by p...

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Detalles Bibliográficos
Autores principales: Olivença, Francisco, Ferreira, Cláudia, Nunes, Alexandra, Silveiro, Cátia, Pimentel, Madalena, Gomes, João Paulo, Catalão, Maria João
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485614/
https://www.ncbi.nlm.nih.gov/pubmed/36147841
http://dx.doi.org/10.3389/fmicb.2022.985871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485614/
https://www.ncbi.nlm.nih.gov/pubmed/36147841
http://dx.doi.org/10.3389/fmicb.2022.985871

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