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Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients

Zonulin has previously been related to intestinal permeability in various inflammatory diseases, and more recently to the physiopathology of severe COVID-19 infections. We analysed serum samples from a previous study of a Peruvian cohort of hospitalised COVID-19 patients, for the quantification of z...

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Autores principales: Palomino-Kobayashi, Luciano A., Ymaña, Barbara, Ruiz, Joaquim, Mayanga-Herrera, Ana, Ugarte-Gil, Manuel F., Pons, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485714/
https://www.ncbi.nlm.nih.gov/pubmed/36147602
http://dx.doi.org/10.3389/fcimb.2022.1000291
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author Palomino-Kobayashi, Luciano A.
Ymaña, Barbara
Ruiz, Joaquim
Mayanga-Herrera, Ana
Ugarte-Gil, Manuel F.
Pons, Maria J.
author_facet Palomino-Kobayashi, Luciano A.
Ymaña, Barbara
Ruiz, Joaquim
Mayanga-Herrera, Ana
Ugarte-Gil, Manuel F.
Pons, Maria J.
author_sort Palomino-Kobayashi, Luciano A.
collection PubMed
description Zonulin has previously been related to intestinal permeability in various inflammatory diseases, and more recently to the physiopathology of severe COVID-19 infections. We analysed serum samples from a previous study of a Peruvian cohort of hospitalised COVID-19 patients, for the quantification of zonulin by sandwich ELISA. Comparisons with clinical data, haematological and biochemical parameters and cytokine/chemokine levels were made. We found higher baseline zonulin levels in deceased patients, and zonulin was associated with fatal outcome in multivariable analyses, even after adjustment for age, gender, and obesity. There were also positive correlations between zonulin, creatinine, D-dimer values and prothrombin time, while inverse correlations were found for Sa/FiO(2) ratio and CCL5 (RANTES). Further longitudinal studies are recommended to analyse the variation of zonulin levels over time as well as their relationship with long-COVID.
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spelling pubmed-94857142022-09-21 Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients Palomino-Kobayashi, Luciano A. Ymaña, Barbara Ruiz, Joaquim Mayanga-Herrera, Ana Ugarte-Gil, Manuel F. Pons, Maria J. Front Cell Infect Microbiol Cellular and Infection Microbiology Zonulin has previously been related to intestinal permeability in various inflammatory diseases, and more recently to the physiopathology of severe COVID-19 infections. We analysed serum samples from a previous study of a Peruvian cohort of hospitalised COVID-19 patients, for the quantification of zonulin by sandwich ELISA. Comparisons with clinical data, haematological and biochemical parameters and cytokine/chemokine levels were made. We found higher baseline zonulin levels in deceased patients, and zonulin was associated with fatal outcome in multivariable analyses, even after adjustment for age, gender, and obesity. There were also positive correlations between zonulin, creatinine, D-dimer values and prothrombin time, while inverse correlations were found for Sa/FiO(2) ratio and CCL5 (RANTES). Further longitudinal studies are recommended to analyse the variation of zonulin levels over time as well as their relationship with long-COVID. Frontiers Media S.A. 2022-09-06 /pmc/articles/PMC9485714/ /pubmed/36147602 http://dx.doi.org/10.3389/fcimb.2022.1000291 Text en Copyright © 2022 Palomino-Kobayashi, Ymaña, Ruiz, Mayanga-Herrera, Ugarte-Gil and Pons https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Palomino-Kobayashi, Luciano A.
Ymaña, Barbara
Ruiz, Joaquim
Mayanga-Herrera, Ana
Ugarte-Gil, Manuel F.
Pons, Maria J.
Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients
title Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients
title_full Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients
title_fullStr Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients
title_full_unstemmed Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients
title_short Zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian COVID-19 patients
title_sort zonulin, a marker of gut permeability, is associated with mortality in a cohort of hospitalised peruvian covid-19 patients
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485714/
https://www.ncbi.nlm.nih.gov/pubmed/36147602
http://dx.doi.org/10.3389/fcimb.2022.1000291
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