Improvement of the sepsis survival rate by adenosine 2a receptor antagonists depends on immune regulatory functions of regulatory T-cells

Adenosine shows a significant immunosuppressive effect in sepsis via binding to the adenosine 2a receptor (A2aR). Both genetic deletion and pharmacological inhibition of the A2aR may improve survival in sepsis. However, available research on this protective mechanism is quite limited. We used an A2a...

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Detalles Bibliográficos
Autores principales: Zhang, Teng, Zhao, Jie, Fu, Jingnan, Chen, Guibing, Ma, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485829/
https://www.ncbi.nlm.nih.gov/pubmed/36148230
http://dx.doi.org/10.3389/fimmu.2022.996446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485829/
https://www.ncbi.nlm.nih.gov/pubmed/36148230
http://dx.doi.org/10.3389/fimmu.2022.996446

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