Cargando…

Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma

BACKGROUND AND PURPOSE: Functional imaging has an established role in therapeutic monitoring of cancer treatments. This study evaluated the correlations of tumour permeability parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and tumour cellularity derived from a...

Descripción completa

Detalles Bibliográficos
Autores principales: Mui, Alan W.L., Lee, Anne W.M., Ng, W.T., Lee, Victor H.F., Vardhanabhuti, Varut, Man, Shei S.Y., Chua, Daniel T.T., Guan, X.Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485900/
https://www.ncbi.nlm.nih.gov/pubmed/36148154
http://dx.doi.org/10.1016/j.phro.2022.09.001
_version_ 1784792161588346880
author Mui, Alan W.L.
Lee, Anne W.M.
Ng, W.T.
Lee, Victor H.F.
Vardhanabhuti, Varut
Man, Shei S.Y.
Chua, Daniel T.T.
Guan, X.Y.
author_facet Mui, Alan W.L.
Lee, Anne W.M.
Ng, W.T.
Lee, Victor H.F.
Vardhanabhuti, Varut
Man, Shei S.Y.
Chua, Daniel T.T.
Guan, X.Y.
author_sort Mui, Alan W.L.
collection PubMed
description BACKGROUND AND PURPOSE: Functional imaging has an established role in therapeutic monitoring of cancer treatments. This study evaluated the correlations of tumour permeability parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and tumour cellularity derived from apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma (NPC). MATERIAL AND METHODS: Twenty NPC patients were examined with DCE-MRI and RESOLVE diffusion-weighted MRI (DW-MRI). Tumour permeability parameters were quantitatively measured with Tofts compartment model. Volume transfer constant (K(trans)), volume of extravascular extracellular space (EES) per unit volume of tissue (V(e)), and the flux rate constant between EES and plasma (K(ep)) from DCE-MRI scan were measured. The time-intensity curve was plotted from the 60 dynamic phases of DCE-MRI. The initial area under the curve for the first 60 s of the contrast agent arrival (iAUC60) was also calculated. They were compared with the ADC value derived from DW-MRI with Pearson correlation analyses. RESULTS: Among the DCE-MRI permeability parameters, K(ep) had higher linearity in inverse correlation with ADC value (r = −0.69, p = <0.05). K(trans) (r = −0.60, p=<0.05) and iAUC60 (r = −0.64, p = <0.05) also had significant inverse correlations with ADC. V(e) showed a significant positive correlation with ADC (r = 0.63, p = <0.05). CONCLUSIONS: Nasopharyngeal tumour vascular permeability parameters derived from DCE-MRI scan were correlated linearly with tumour cellularity measured by free water diffusability with ADC. The clinical implementations of these linear correlations in the quantitative assessments of therapeutic response for NPC patients may be worth to further explore.
format Online
Article
Text
id pubmed-9485900
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-94859002022-09-21 Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma Mui, Alan W.L. Lee, Anne W.M. Ng, W.T. Lee, Victor H.F. Vardhanabhuti, Varut Man, Shei S.Y. Chua, Daniel T.T. Guan, X.Y. Phys Imaging Radiat Oncol Original Research Article BACKGROUND AND PURPOSE: Functional imaging has an established role in therapeutic monitoring of cancer treatments. This study evaluated the correlations of tumour permeability parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and tumour cellularity derived from apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma (NPC). MATERIAL AND METHODS: Twenty NPC patients were examined with DCE-MRI and RESOLVE diffusion-weighted MRI (DW-MRI). Tumour permeability parameters were quantitatively measured with Tofts compartment model. Volume transfer constant (K(trans)), volume of extravascular extracellular space (EES) per unit volume of tissue (V(e)), and the flux rate constant between EES and plasma (K(ep)) from DCE-MRI scan were measured. The time-intensity curve was plotted from the 60 dynamic phases of DCE-MRI. The initial area under the curve for the first 60 s of the contrast agent arrival (iAUC60) was also calculated. They were compared with the ADC value derived from DW-MRI with Pearson correlation analyses. RESULTS: Among the DCE-MRI permeability parameters, K(ep) had higher linearity in inverse correlation with ADC value (r = −0.69, p = <0.05). K(trans) (r = −0.60, p=<0.05) and iAUC60 (r = −0.64, p = <0.05) also had significant inverse correlations with ADC. V(e) showed a significant positive correlation with ADC (r = 0.63, p = <0.05). CONCLUSIONS: Nasopharyngeal tumour vascular permeability parameters derived from DCE-MRI scan were correlated linearly with tumour cellularity measured by free water diffusability with ADC. The clinical implementations of these linear correlations in the quantitative assessments of therapeutic response for NPC patients may be worth to further explore. Elsevier 2022-09-12 /pmc/articles/PMC9485900/ /pubmed/36148154 http://dx.doi.org/10.1016/j.phro.2022.09.001 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Mui, Alan W.L.
Lee, Anne W.M.
Ng, W.T.
Lee, Victor H.F.
Vardhanabhuti, Varut
Man, Shei S.Y.
Chua, Daniel T.T.
Guan, X.Y.
Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
title Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
title_full Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
title_fullStr Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
title_full_unstemmed Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
title_short Correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
title_sort correlations of tumour permeability parameters with apparent diffusion coefficient in nasopharyngeal carcinoma
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9485900/
https://www.ncbi.nlm.nih.gov/pubmed/36148154
http://dx.doi.org/10.1016/j.phro.2022.09.001
work_keys_str_mv AT muialanwl correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT leeannewm correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT ngwt correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT leevictorhf correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT vardhanabhutivarut correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT mansheisy correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT chuadanieltt correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma
AT guanxy correlationsoftumourpermeabilityparameterswithapparentdiffusioncoefficientinnasopharyngealcarcinoma