Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice

OBJECTIVES: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but where they are secreted from and what they are require...

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Detalles Bibliográficos
Autores principales: Patel, Satish, Haider, Afreen, Alvarez-Guaita, Anna, Bidault, Guillaume, El-Sayed Moustafa, Julia Sarah, Guiu-Jurado, Esther, Tadross, John A., Warner, James, Harrison, James, Virtue, Samuel, Scurria, Fabio, Zvetkova, Ilona, Blüher, Matthias, Small, Kerrin S., O’Rahilly, Stephen, Savage, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486046/
https://www.ncbi.nlm.nih.gov/pubmed/36064109
http://dx.doi.org/10.1016/j.molmet.2022.101589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486046/
https://www.ncbi.nlm.nih.gov/pubmed/36064109
http://dx.doi.org/10.1016/j.molmet.2022.101589

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