Rare POLN mutations confer risk for familial nasopharyngeal carcinoma through weakened Epstein-Barr virus lytic replication

BACKGROUND: Nasopharyngeal carcinoma (NPC) exhibits significant familial aggregation; however, its susceptibility genes are largely unknown. Thus, this study aimed to identify germline mutations that might contribute to the risk of familial NPC, and explore their biological functions. METHODS: Whole...

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Detalles Bibliográficos
Autores principales: Xiao, Ruo-Wen, Wang, Fang, Wang, Tong-Min, Zhang, Jiang-Bo, Wu, Zi-Yi, Deng, Chang-Mi, Liao, Ying, Zhou, Ting, Yang, Da-Wei, Dong, Si-Qi, Xue, Wen-Qiong, He, Yong-Qiao, Zheng, Xiao-Hui, Li, Xi-Zhao, Zhang, Pei-Fen, Zhang, Shao-Dan, Hu, Ye-Zhu, Liu, Yu-Ying, Xia, Yun-Fei, Gao, Song, Mu, Jian-Bing, Feng, Lin, Jia, Wei-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486052/
https://www.ncbi.nlm.nih.gov/pubmed/36116213
http://dx.doi.org/10.1016/j.ebiom.2022.104267

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