Balancing cell polarity PARts through dephosphorylation

How cells spatially organize their plasma membrane, cytoskeleton, and cytoplasm remains a central question for cell biologists. In this issue of JCB, Calvi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202201048) identify PP1 phosphatases as key regulators of C. elegans anterior–posterior...

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Detalles Bibliográficos
Autores principales: Barros-Carvalho, André, Morais-de-Sá, Eurico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486083/
https://www.ncbi.nlm.nih.gov/pubmed/36121422
http://dx.doi.org/10.1083/jcb.202208008
Descripción
Sumario:How cells spatially organize their plasma membrane, cytoskeleton, and cytoplasm remains a central question for cell biologists. In this issue of JCB, Calvi et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202201048) identify PP1 phosphatases as key regulators of C. elegans anterior–posterior polarity, by counterbalancing aPKC-mediated phosphorylation of PAR-2.

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