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Crystal structures of Schistosoma mansoni histone deacetylase 8 reveal a novel binding site for allosteric inhibitors

Parasitic diseases cause significant global morbidity and mortality particularly in the poorest regions of the world. Schistosomiasis, one of the most widespread neglected tropical diseases, affects more than 200 million people worldwide. Histone deacetylase (HDAC) inhibitors are prominent epigeneti...

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Detalles Bibliográficos
Autores principales:	Saccoccia, Fulvio, Pozzetti, Luca, Gimmelli, Roberto, Butini, Stefania, Guidi, Alessandra, Papoff, Giuliana, Giannaccari, Marialaura, Brogi, Simone, Scognamiglio, Viviana, Gemma, Sandra, Ruberti, Giovina, Campiani, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486128/ https://www.ncbi.nlm.nih.gov/pubmed/35970392 http://dx.doi.org/10.1016/j.jbc.2022.102375

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