An evolutionary divergent thermodynamic brake in ZAP-70 fine-tunes the kinetic proofreading in T cells

T cell signaling starts with assembling several tyrosine kinases and adapter proteins to the T cell receptor (TCR), following the antigen binding to the TCR. The stability of the TCR–antigen complex and the delay between the recruitment and activation of each kinase determines the T cell response. I...

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Detalles Bibliográficos
Autores principales: Gangopadhyay, Kaustav, Roy, Arnab, Chandradasan, Athira C., Roy, Swarnendu, Debnath, Olivia, SenGupta, Soumee, Chowdhury, Subhankar, Das, Dipjyoti, Das, Rahul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486129/
https://www.ncbi.nlm.nih.gov/pubmed/35970395
http://dx.doi.org/10.1016/j.jbc.2022.102376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486129/
https://www.ncbi.nlm.nih.gov/pubmed/35970395
http://dx.doi.org/10.1016/j.jbc.2022.102376

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