HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells

Purinostat Mesylate (PM) is a novel highly selective and active HDAC I/IIb inhibitor, and the injectable formulation of PM (PMF) based on the compound prescription containing cyclodextrin completely can overcome PM's poor solubility and improves its stability and pharmacokinetic properties. Her...

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Detalles Bibliográficos
Autores principales: Qiu, Qiang, yang, Linyu, Feng, Yunyu, Zhu, Zejiang, Li, Ning, Zheng, Li, Sun, Yuanyuan, Pan, Cong, Qiu, Huandi, Cui, Xue, He, Wei, Wang, Fang, Yi, Yuyao, Tang, Minghai, Yang, Zhuang, Yang, Yunfan, Li, Zhihui, Chen, Lijuan, Hu, Yiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486186/
https://www.ncbi.nlm.nih.gov/pubmed/36185739
http://dx.doi.org/10.1016/j.bioactmat.2022.08.006

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