Cargando…

Randomized, placebo-controlled, single-blind phase 1 studies of the safety, tolerability, and pharmacokinetics of BRII-196 and BRII-198, SARS-CoV-2 spike-targeting monoclonal antibodies with an extended half-life in healthy adults

Background: BRII-196 and BRII-198 are two anti-SARS-CoV-2 monoclonal neutralizing antibodies as a cocktail therapy for treating COVID-19 with a modified Fc region that extends half-life. Methods: Safety, tolerability, pharmacokinetics, and immunogenicity of BRII-196 and BRII-198 were investigated in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Xiaohua, Zhang, Zheng, Ma, Ji, Cheng, Lin, Ji, Yun, Liu, Yang, Zhao, Dong, Zhang, Wen, Li, Chunming, Yan, Li, Margolis, David, Zhu, Qing, Zhang, Yao, Zhang, Fujie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486188/ https://www.ncbi.nlm.nih.gov/pubmed/36147329 http://dx.doi.org/10.3389/fphar.2022.983505

Ejemplares similares

520. Pharmacokinetic and Safety Phase 1 Study and Microneutralization Assay Results with BRII-196/BRII-198, a Novel Antibody Cocktail Active Against a Wide Range of SARS-CoV-2 Variants
por: Margolis, David A, et al.
Publicado: (2021)

LB2. Safety and Efficacy of Combination SARS-CoV-2 Monoclonal Neutralizing Antibodies (mAb) BRII-196 and BRII-198 in Non-Hospitalized COVID-19 Patients
por: Evering, Teresa H, et al.
Publicado: (2021)

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
Publicado: (2022)

Effect of the Timing of Amubarvimab/Romlusevimab (BRII-196/198) Administration on Progression to Severe Disease in Elderly Patients with COVID-19 Infection: A Retrospective Cohort Study
por: Xu, Yonghao, et al.
Publicado: (2023)

1283. Safety, Tolerability, and Pharmacokinetics of BRII-778, A Modified-Release Oral Formulation of Rilpivirine in Healthy Adult Subjects
por: Margolis, David A, et al.
Publicado: (2022)

Therapeutic vaccine BRII-179 restores HBV-specific immune responses in patients with chronic HBV in a phase Ib/IIa study
por: Ma, Haiyan, et al.
Publicado: (2021)

Collectivity in ${}^{\mathrm{196,198}}$Pb isotopes probed in Coulomb-excitation experiments at REX-ISOLDE
por: Pakarinen, J, et al.
Publicado: (2017)

Monoclonal Antibodies with Extended Half-Life to Prevent Covid-19
por: Abraham, Jonathan
Publicado: (2022)

A Physiologically‐Based Pharmacokinetic Model for the Prediction of “Half‐Life Extension” and “Catch and Release” Monoclonal Antibody Pharmacokinetics
por: Jones, Hannah M., et al.
Publicado: (2020)

Single Amino Acids G196 and R198 in hr1 of Subgroup K Avian Leukosis Virus Glycoprotein Are Critical for Tva Receptor Binding
por: Chen, Jian, et al.
Publicado: (2020)

Safety, Tolerability, and Pharmacokinetics of MEDI8897, the Respiratory Syncytial Virus Prefusion F-Targeting Monoclonal Antibody with an Extended Half-Life, in Healthy Adults
por: Griffin, M. Pamela, et al.
Publicado: (2017)

Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults
por: Yu, Xiang-Qing, et al.
Publicado: (2016)

Tyr198 is the Essential Autophosphorylation Site for STK16 Localization and Kinase Activity
por: Wang, Junjun, et al.
Publicado: (2019)

Predicted effectiveness of vaccines and extended half-life monoclonal antibodies against RSV hospitalizations in children
por: Zheng, Zhe, et al.
Publicado: (2022)

Transfer results for odd-odd $^{198}$Au as a test of extended supersymmetry
por: Berrier-Ronsin, G, et al.
Publicado: (1996)

In silico comparison of pharmacokinetic properties of three extended half-life factor IX concentrates
por: Preijers, Tim, et al.
Publicado: (2021)

G196 epitope tag system: a novel monoclonal antibody, G196, recognizes the small, soluble peptide DLVPR with high affinity
por: Tatsumi, Kasumi, et al.
Publicado: (2017)

Safety, Tolerability and Pharmacokinetics of Half-Life Extended Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Monoclonal Antibodies AZD7442 (Tixagevimab-Cilgavimab) in Healthy Adults
por: Forte-Soto, Pablo, et al.
Publicado: (2023)

Combined Elevation of microRNA-196a and microRNA-196b in Sera Predicts Unfavorable Prognosis in Patients with Osteosarcomas
por: Zhang, Chun, et al.
Publicado: (2014)

Predictive Potential of BCS and Pharmacokinetic Parameters on Study Outcome: Analysis of 198 In Vivo Bioequivalence Studies
por: Krajcar, Dejan, et al.
Publicado: (2023)

Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin
por: Roy, Chad J., et al.
Publicado: (2020)

Cesarean scar endometriosis: presentation of 198 cases and literature review
por: Zhang, Ping, et al.
Publicado: (2019)

Extended half‐life factor VIII concentrates in adults with hemophilia A: Comparative pharmacokinetics of two products
por: Teitel, Jerome, et al.
Publicado: (2021)

Alpha decay of $^{198}$Rn
por: Calaprice, F P, et al.
Publicado: (1984)

Pharmacokinetics of Monoclonal Antibodies
por: Ryman, Josiah T., et al.
Publicado: (2017)

GT198 Is a Target of Oncology Drugs and Anticancer Herbs
por: Pang, Junfeng, et al.
Publicado: (2021)

Safety, Tolerability and Pharmacokinetics of MEDI8897, an Extended Half-life Single-dose Respiratory Syncytial Virus Prefusion F-targeting Monoclonal Antibody Administered as a Single Dose to Healthy Preterm Infants
por: Domachowske, Joseph B., et al.
Publicado: (2018)

1557. Population Pharmacokinetics of Suvratoxumab (MEDI4893), an Extended Half-life Staphylococcus aureus Alpha Toxin-Neutralizing Human Monoclonal Antibody, in Healthy Adults and Patients on Mechanical Ventilation in Intensive Care Units
por: Pierre, Vadryn, et al.
Publicado: (2019)

198. Comparison of Standard versus Extended Treatment Duration for Gram-negative Bloodstream Infections with Obstructing Nephrolithiasis or Urolithiasis
por: Harpenau, Tara L, et al.
Publicado: (2023)

Health Tract, No. 198: Balm of Gilead
Publicado: (1865)

Clinical characteristics and prognosis of 196 Chinese patients with colon cancer
por: Yao, Lunjin, et al.
Publicado: (2023)

Chimeric antibodies with extended half-life in ferrets
por: Nesspor, Thomas C, et al.
Publicado: (2014)

Effect of FAM196B in human lung adenocarcinoma
por: Feng, Yu, et al.
Publicado: (2018)

Relative efficacy of egg yolk and soya milk-based extenders for cryopreservation (−196°C) of buffalo semen
por: Chaudhari, D.V., et al.
Publicado: (2015)

Favorable Pharmacokinetic Characteristics of Extended-Half-Life Recombinant Factor VIII BAY 94-9027 Enable Robust Individual Profiling Using a Population Pharmacokinetic Approach
por: Solms, Alexander, et al.
Publicado: (2019)

Neuroprotective Effect of SCM-198 through Stabilizing Endothelial Cell Function
por: Zhang, Qiu-Yan, et al.
Publicado: (2019)

Fast extraction for ps196
por: Roux, E
Publicado: (1994)

The charge radii of $^{198}$Pt - $^{183}$Pt
por: Hilberath, T, et al.
Publicado: (1989)

Au-198m as novel PAC probe
por: Correia, Guilherme, et al.
Publicado: (2023)

S198. SELF-DISTURBANCES AND THEIR NEURAL SIGNATURES IN SCHIZOPHRENIA
por: Zaytseva, Yulia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fadfnn1r15t59mr5kgjip0jnsn