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A recipe for a good clinical pulmonary surfactant

The lives of thousands premature babies have been saved along the last thirty years thanks to the establishment and consolidation of pulmonary surfactant replacement therapies (SRT). It took some time to close the gap between the identification of the biophysical and molecular causes of the high mor...

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Autor principal: Pérez-Gil, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486245/
https://www.ncbi.nlm.nih.gov/pubmed/35272060
http://dx.doi.org/10.1016/j.bj.2022.03.001
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author Pérez-Gil, Jesús
author_facet Pérez-Gil, Jesús
author_sort Pérez-Gil, Jesús
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description The lives of thousands premature babies have been saved along the last thirty years thanks to the establishment and consolidation of pulmonary surfactant replacement therapies (SRT). It took some time to close the gap between the identification of the biophysical and molecular causes of the high mortality associated with respiratory distress syndrome in very premature babies and the development of a proper therapy. Closing the gap required the elucidation of some key questions defining the structure–function relationships in surfactant as well as the particular role of the different molecular components assembled into the surfactant system. On the other hand, the application of SRT as part of treatments targeting other devastating respiratory pathologies, in babies and adults, is depending on further extensive research still required before enough amounts of good humanized clinical surfactants will be available. This review summarizes our current concepts on the compositional and structural determinants defining pulmonary surfactant activity, the principles behind the development of efficient natural animal-derived or recombinant or synthetic therapeutic surfactants, as well as a the most promising lines of research that are already opening new perspectives in the application of tailored surfactant therapies to treat important yet unresolved respiratory pathologies.
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spelling pubmed-94862452022-09-26 A recipe for a good clinical pulmonary surfactant Pérez-Gil, Jesús Biomed J Review Article The lives of thousands premature babies have been saved along the last thirty years thanks to the establishment and consolidation of pulmonary surfactant replacement therapies (SRT). It took some time to close the gap between the identification of the biophysical and molecular causes of the high mortality associated with respiratory distress syndrome in very premature babies and the development of a proper therapy. Closing the gap required the elucidation of some key questions defining the structure–function relationships in surfactant as well as the particular role of the different molecular components assembled into the surfactant system. On the other hand, the application of SRT as part of treatments targeting other devastating respiratory pathologies, in babies and adults, is depending on further extensive research still required before enough amounts of good humanized clinical surfactants will be available. This review summarizes our current concepts on the compositional and structural determinants defining pulmonary surfactant activity, the principles behind the development of efficient natural animal-derived or recombinant or synthetic therapeutic surfactants, as well as a the most promising lines of research that are already opening new perspectives in the application of tailored surfactant therapies to treat important yet unresolved respiratory pathologies. Chang Gung University 2022-08 2022-03-08 /pmc/articles/PMC9486245/ /pubmed/35272060 http://dx.doi.org/10.1016/j.bj.2022.03.001 Text en © 2022 Chang Gung University. Publishing services by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Pérez-Gil, Jesús
A recipe for a good clinical pulmonary surfactant
title A recipe for a good clinical pulmonary surfactant
title_full A recipe for a good clinical pulmonary surfactant
title_fullStr A recipe for a good clinical pulmonary surfactant
title_full_unstemmed A recipe for a good clinical pulmonary surfactant
title_short A recipe for a good clinical pulmonary surfactant
title_sort recipe for a good clinical pulmonary surfactant
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486245/
https://www.ncbi.nlm.nih.gov/pubmed/35272060
http://dx.doi.org/10.1016/j.bj.2022.03.001
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