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General mechanism of spider toxin family I acting on sodium channel Nav1.7

Various peptide toxins in animal venom inhibit voltage-gated sodium ion channel Nav1.7, including Nav-targeting spider toxin (NaSpTx) Family I. Toxins in NaSpTx Family I share a similar structure, i.e., N-terminal, loops 1–4, and C-terminal. Here, we used Mu-theraphotoxin-Ca2a (Ca2a), a peptide isol...

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Detalles Bibliográficos
Autores principales:	Yuan, Fu-Chu, Sun, Fu-De, Zhang, Lin, Huang, Biao, An, Hai-Long, Rong, Ming-Qiang, Du, Can-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Science Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486512/ https://www.ncbi.nlm.nih.gov/pubmed/36052553 http://dx.doi.org/10.24272/j.issn.2095-8137.2022.185

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