A disordered region retains the full protease inhibitor activity and the capacity to induce CD8(+) T cells in vivo of the oral vaccine adjuvant U-Omp19

U-Omp19 is a bacterial protease inhibitor from Brucella abortus that inhibits gastrointestinal and lysosomal proteases, enhancing the half-life and immunogenicity of co-delivered antigens. U-Omp19 is a novel adjuvant that is in preclinical development with various vaccine candidates. However, the mo...

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Detalles Bibliográficos
Autores principales: Laura Darriba, M., Castro, Celeste Pueblas, Coria, Lorena M., Bruno, Laura, Laura Cerutti, M., Otero, Lisandro H., Chemes, Lucía B., Rasia, Rodolfo M., Klinke, Sebastián, Cassataro, Juliana, Pasquevich, Karina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486555/
https://www.ncbi.nlm.nih.gov/pubmed/36187929
http://dx.doi.org/10.1016/j.csbj.2022.08.054

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