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Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review
This scoping review systematically reviewed relevant research to summarize the literature addressing the significance of monitoring spinal cord perfusion pressure (SCPP) in acute traumatic spinal cord injury (SCI). The objectives of the review were to (1) examine the nature of research in the field...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486559/ https://www.ncbi.nlm.nih.gov/pubmed/36147378 http://dx.doi.org/10.1016/j.jcot.2022.102024 |
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author | Gee, Cameron M. Kwon, Brian K. |
author_facet | Gee, Cameron M. Kwon, Brian K. |
author_sort | Gee, Cameron M. |
collection | PubMed |
description | This scoping review systematically reviewed relevant research to summarize the literature addressing the significance of monitoring spinal cord perfusion pressure (SCPP) in acute traumatic spinal cord injury (SCI). The objectives of the review were to (1) examine the nature of research in the field of SCPP monitoring in SCI, (2) summarize the key research findings in the field, and (3) identify research gaps in the existing literature and future research priorities. Primary literature searches were conducted using databases (Medline and Embase) and expanded searches were conducted by reviewing the references of eligible articles and searches of Scopus, Web of Science core collection, Google Scholar, and conference abstracts. Relevant data were extracted from the studies and synthesis of findings was guided by the identification of patterns across studies to identify key themes and research gaps within the literature. Following primary and expanded searches, a total of 883 articles were screened. Seventy-three articles met the review inclusion criteria, including 34 original research articles. Other articles were categorized as conference abstracts, literature reviews, systematic reviews, letters to the editor, perspective articles, and editorials. Key themes relevant to the research question that emerged from the review included the relationship between SCPP and neurological recovery, the safety of monitoring pressures within the intrathecal space, and methods of intervention to enhance SCPP in the setting of acute traumatic SCI. Original research that aims to enhance SCPP by targeting increases in mean arterial pressure or reducing pressure in the intrathecal space is reviewed. Further discussion regarding where pressure within the intrathecal space should be measured is provided. Finally, we highlight research gaps in the literature such as determining the feasibility of invasive monitoring at smaller centers, the need for a better understanding of cerebrospinal fluid physiology following SCI, and novel pharmacological interventions to enhance SCPP in the setting of acute traumatic SCI. Ultimately, despite a growing body of literature on the significance of SCPP monitoring following SCI, there are still a number of important knowledge gaps that will require further investigation. |
format | Online Article Text |
id | pubmed-9486559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-94865592023-09-11 Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review Gee, Cameron M. Kwon, Brian K. J Clin Orthop Trauma Spine This scoping review systematically reviewed relevant research to summarize the literature addressing the significance of monitoring spinal cord perfusion pressure (SCPP) in acute traumatic spinal cord injury (SCI). The objectives of the review were to (1) examine the nature of research in the field of SCPP monitoring in SCI, (2) summarize the key research findings in the field, and (3) identify research gaps in the existing literature and future research priorities. Primary literature searches were conducted using databases (Medline and Embase) and expanded searches were conducted by reviewing the references of eligible articles and searches of Scopus, Web of Science core collection, Google Scholar, and conference abstracts. Relevant data were extracted from the studies and synthesis of findings was guided by the identification of patterns across studies to identify key themes and research gaps within the literature. Following primary and expanded searches, a total of 883 articles were screened. Seventy-three articles met the review inclusion criteria, including 34 original research articles. Other articles were categorized as conference abstracts, literature reviews, systematic reviews, letters to the editor, perspective articles, and editorials. Key themes relevant to the research question that emerged from the review included the relationship between SCPP and neurological recovery, the safety of monitoring pressures within the intrathecal space, and methods of intervention to enhance SCPP in the setting of acute traumatic SCI. Original research that aims to enhance SCPP by targeting increases in mean arterial pressure or reducing pressure in the intrathecal space is reviewed. Further discussion regarding where pressure within the intrathecal space should be measured is provided. Finally, we highlight research gaps in the literature such as determining the feasibility of invasive monitoring at smaller centers, the need for a better understanding of cerebrospinal fluid physiology following SCI, and novel pharmacological interventions to enhance SCPP in the setting of acute traumatic SCI. Ultimately, despite a growing body of literature on the significance of SCPP monitoring following SCI, there are still a number of important knowledge gaps that will require further investigation. Elsevier 2022-09-11 /pmc/articles/PMC9486559/ /pubmed/36147378 http://dx.doi.org/10.1016/j.jcot.2022.102024 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Spine Gee, Cameron M. Kwon, Brian K. Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review |
title | Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review |
title_full | Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review |
title_fullStr | Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review |
title_full_unstemmed | Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review |
title_short | Significance of spinal cord perfusion pressure following spinal cord injury: A systematic scoping review |
title_sort | significance of spinal cord perfusion pressure following spinal cord injury: a systematic scoping review |
topic | Spine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9486559/ https://www.ncbi.nlm.nih.gov/pubmed/36147378 http://dx.doi.org/10.1016/j.jcot.2022.102024 |
work_keys_str_mv | AT geecameronm significanceofspinalcordperfusionpressurefollowingspinalcordinjuryasystematicscopingreview AT kwonbriank significanceofspinalcordperfusionpressurefollowingspinalcordinjuryasystematicscopingreview |